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c/sideeffects·submitted 1 year ago by u/rania_diallo

the nausea thing finally clicked for me and I want to write it down

Resolvedbranch of 12 comments

the nausea thing finally clicked for me and I want to write it down. Not a hot take, just something I have not seen said plainly here. The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board…

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12 comments, started 1 year ago
u/signe_villalobos353 points·1 year ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 57 probably does not, and that is worth saying to a clinician rather than to us.

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u/blank_injection289 points·1 year ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/ferran_krastev75 points·1 year ago

Held the dose for an extra six weeks instead of stepping. The muscle cramps settled and I lost the same amount anyway.

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u/ahmed_rasmussen-18 points·1 year ago

Same pattern here. It settled at a stable dose without me doing anything clever.

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[removed]1 point·1 year ago

[removed by moderator]

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u/fatima_asante118 points·1 year ago

Right, and the hair thing is worth repeating: it tracks the rate of loss rather than the compound, and it stops.

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u/ayesha_radich77 points·1 year ago·edited

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/bastian_eriksen20 points·1 year ago

if it is severe or persistent that is a clinician question, not a board question

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u/priya_weiss10 points·1 year ago

Agreed. Slowing down at meals did more for my constipation than everything I bought to fix it, which was embarrassing to discover.

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u/aa_analysis_andy63 points·1 year ago

nobody warns you about how much of this is timing rather than dose

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u/zaid_balogun18 points·1 year ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/rina_bergstrom260 points·1 year ago

Bought four different things to fix my reflux. What actually worked was eating half as fast.

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