[Side Effects] the sulphur burps are real and they do pass
Something I keep coming back to: the sulphur burps are real and they do pass.
reflux made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.
What I would tell week-one me, in order of how much time it would have saved.
One: the first month is a tolerance check. You are finding out whether you can take this, not how much you will lose. Two: write down the dose, the day and the waist measurement. Three: a stall of under six weeks is weather, not climate. Four: sulphur burps that arrives the day after the shot and fades by day four is the ordinary pattern and it usually settles at a stable dose.
None of that is advice about what you should do. It is the shape of the thing, which nobody explained to me and which the wiki explains better than I just did.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.
best — the order this archive was captured in
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chem
vikram_ferreira is describing the standard shape here and it matches the trial data better than most anecdotes do.
This matches me almost exactly, right down to the sulphur burps showing up on the second day and being gone by the fourth.
This matches me almost exactly, right down to the sulphur burps showing up on the second day and being gone by the fourth.
Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.
if 1.0mg is working there is no prize for going up
sema is weekly for a reason, the half-life does the smoothing
the appetite signal and the scale move on different clocks
the ladder exists because the gut needs the time, not because the pharmacy likes paperwork
What dose and how many weeks at it before this started?
Kept a log from week one and the single most useful column turned out to be waist, not weight.
Kept a log from week one and the single most useful column turned out to be waist, not weight.
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.
Right, and the timescale is the bit that keeps getting lost.
This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
Right, and the timescale is the bit that keeps getting lost.
Disagree with this specific line. A pause at 1.0mg is not evidence that 1.0mg has stopped working.
That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
Not convinced. You changed the dose and the week at the same time, so you cannot attribute the change to either.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
protein first, then everything else gets easier
- 1Research-use-only material is not approved for human use, so anything in…9 comments in this branch · started by u/vikram_ferreira
- 2Kept a log from week one and the single most useful column turned out to be…6 comments in this branch · started by u/freya_baptista