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c/semaglutide·posted 1 months ago by u/bilal_osei

does anyone else get one good week and one flat week on repeat

Question

Slightly embarrassed to be asking this, but: does anyone else get one good week and one flat week on repeat.

reflux made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.

What I would tell week-one me, in order of how much time it would have saved.

One: the first month is a tolerance check. You are finding out whether you can take this, not how much you will lose. Two: write down the dose, the day and the waist measurement. Three: a stall of under six weeks is weather, not climate. Four: early fullness that arrives the day after the shot and fades by day four is the ordinary pattern and it usually settles at a stable dose.

None of that is advice about what you should do. It is the shape of the thing, which nobody explained to me and which the wiki explains better than I just did.

The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.

Happy to answer the boring questions. Those are usually the ones worth asking.

188 up / 59 down76% upvoted19 commentsid 1d7yd428 Jun 2026

19 comments

15 in this archive, depth 5

best — the order this archive was captured in

u/chidi_demir14 points·1 months ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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u/leila_vasquez4 points·1 months ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg.

chidi_demir is describing the standard shape here and it matches the trial data better than most anecdotes do.

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u/leila_silva10 points·1 months ago

Kept a log from week one and the single most useful column turned out to be waist, not weight.

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u/oskar_ibarra6 points·1 months ago

I would push back gently. Going up because the scale paused is the single most common mistake described on this board.

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u/teodor_duarte3 points·1 months ago

the food noise going quiet is the effect people actually describe

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u/kavya_radich1 point·29 days ago

sema is weekly for a reason, the half-life does the smoothing

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u/katrin_diallo1 point·29 days ago

2.4 is a ceiling, not a target

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u/rafael_ostergaard7 points·1 months ago

do not chase somebody else’s titration schedule, they are not you

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u/rafael_ostergaard0 points·1 months ago

Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.

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u/hugo_bergstrom1 point·1 months ago

the first four weeks are a tolerance check, not a weight-loss phase

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