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c/tapering·posted 1 year ago by u/aleksi_lehtinen

how much of what we believe about appetite return actually comes from regain threads

Regain Receipts ×7 Long Haul ×2

The title is the whole question — how much of what we believe about appetite return actually comes from regain threads — but here is why I am asking.

Nothing on this board is a taper schedule, and no member can write one for another. What can be shared is what people watched and what they observed.

There is very little published guidance on stopping specifically, which is exactly why board consensus here should carry less weight than usual and a clinician conversation should carry more.

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

Would rather be corrected in public than confident in private.

1,964 up / 87 down96% upvoted48 commentsid iz33c711 Jun 2025

48 comments

28 in this archive, depth 6

best — the order this archive was captured in

u/taper_off_tabithaMOD311 points·1 year ago

Removed the taper schedule written for another member. Describe your own experience instead.

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u/quiet_reader_99131 points·1 year ago

Stretched from seven days to ten to twelve over four months. Appetite told me where the limit was each time.

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u/lane_watchermod · logistics29 points·1 year ago

coming back later is allowed and it is common

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u/adaeze_brandt18 points·1 year ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/valeria_girard190 points·1 year ago

appetite comes back before the weight does

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u/naomi_ekstrom59 points·1 year ago

Small fix — you have described interval stretching and called it a taper. The exposure profiles differ.

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u/preservative_free_p157 points·1 year ago

have the conversation with a clinician before, not after

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u/injection_site_iris132 points·1 year ago

Cosigning that cost and supply are legitimate reasons. Most of the stopping threads here are one of those two.

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u/dario_stanescu108 points·1 year ago

write down where you are before you change anything

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u/TitrationTortoiseslow and boring144 points·1 year ago

Correction: that study measured regain after discontinuation, not loss of effect during treatment. Very different findings.

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u/cormac_roos161 points·1 year ago·edited

Push back: that is a taper schedule aimed at another member and this board does not host those.

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u/adaeze_weiss88 points·1 year ago

Is this a pause or a stop? They are different plans.

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u/anders_kuusela118 points·1 year ago

Stopped for cost reasons. Appetite came back at about week 22, well before the scale moved, exactly as this board said it would.

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u/border_paperwork-22 points·1 year ago

Agreed that returning later is common and it is treated here as ordinary rather than as a defeat.

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u/coa_janitormod · c/coa-26 points·1 year ago

What the evidence says about stopping, written plainly because the framing does real damage.

Withdrawal studies across this class consistently show substantial regain after discontinuation. Appetite typically returns first, well before weight changes. This is a finding about the pharmacology of a chronic condition, in the same way that blood pressure rises again when an antihypertensive is stopped.

People on this board quit in shame over an entirely predictable result, and then avoid coming back because they have interpreted it as a personal failure. It is not. Knowing that in advance is the single most useful thing this board can offer anybody planning to stop.

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u/controversial_only60 points·1 year ago

Same. A quiet fortnight after stopping tells you very little; the interesting part starts later.

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u/aleksi_lehtinenOP31 points·1 year ago

That is a pause rather than a stop, and the plans for the two are not the same.

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u/appeal_letter_al10 points·1 year ago

nobody here can write you a taper schedule

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u/dario_vermeulen24 points·1 year ago

a fortnight of nothing is not evidence that you are fine

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u/pavel_halvorsen20 points·1 year ago

Not convinced. Two weeks of stable weight is not evidence of anything yet.

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u/ahmed_cardoso16 points·1 year ago

Right, and the habits from the losing phase are the part that has to outlive the dose.

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u/zeynep_weiss6 points·1 year ago

the habits are what has to carry it afterwards

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u/quarter_dose_queenlow and slow8 points·1 year ago

Yes — the withdrawal literature is consistent and it is a pharmacological finding, not a moral one.

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u/viktor_laurent5 points·1 year ago

stopping is a plan, not an event

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u/aleksi_lehtinenOP3 points·1 year ago

Correcting myself upthread: appetite returned at week 13 for me, not the week I posted.

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u/janek_ferrari1 point·1 year ago

cost and supply are the two most common reasons and both are legitimate

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[deleted]1 point·1 year ago

[deleted]

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u/vikram_asante19 points·1 year ago

stopping abruptly and stopping gradually are different experiences

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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