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c/tapering·posted 6 months ago by u/lina_adebayo

week 59 check-in — 30kg down, nausea manageable, one thing confusing me

Trial Data Clean Column ×3 Sourced ×2

Here it is: week 59 check-in — 30kg down, nausea manageable, one thing confusing me. One person, one log, no control group, so read it accordingly.

week 59 and 30kg — those are the numbers, and they are the ones I am willing to defend.

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

There is very little published guidance on stopping specifically, which is exactly why board consensus here should carry less weight than usual and a clinician conversation should carry more.

Tell me where this is wrong. That is the useful part of posting it.

1,895 up / 337 down85% upvoted59 commentsid 1i7uxf21 Jan 2026

59 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/TitrationTortoiseslow and boring169 points·6 months ago

Nothing on this board is a taper schedule, and no member can write one for another. What can be shared is what people watched and what they observed.

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u/honest_syringe_2025107 points·6 months ago

Nothing on this board is a taper schedule, and no member can write one for another.

TitrationTortoise is right that regain is a documented outcome rather than a character verdict.

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u/salma_vasquez58 points·6 months ago

watch appetite, not the scale, for the first month

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u/adaeze_brandt69 points·6 months ago

Stretching the interval or reducing the dose?

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u/ferran_krastev33 points·6 months ago

Stretching the interval or reducing the dose?

Disagreeing with this bit: stretching and reducing are different things and the post treats them as one.

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[deleted]14 points·6 months ago

[deleted]

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u/micro_bump_mick19 points·6 months ago

stopping abruptly and stopping gradually are different experiences

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u/ilias_kaufmann12 points·6 months ago

a fortnight of nothing is not evidence that you are fine

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u/zeynep_zielinski6 points·6 months ago

Agreed. Appetite is the leading indicator and the scale is the lagging one. Watch the first, not the second.

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u/zeynep_ndiaye-6 points·6 months ago

Stretched from seven days to ten to twelve over four months. Appetite told me where the limit was each time.

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u/naomi_ekstrom71 points·6 months ago

stopping is a plan, not an event

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u/malin_petrescu30 points·6 months ago

Careful — interval stretching and dose reduction are different interventions and your post uses them interchangeably.

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u/vikram_ferreira9 points·6 months ago

have the conversation with a clinician before, not after

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u/adaeze_weiss4 points·6 months ago

Cosigning that cost and supply are legitimate reasons. Most of the stopping threads here are one of those two.

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u/lina_adebayoOP3 points·6 months ago

Cosigning that cost and supply are legitimate reasons.

Adding the one process step — write down where you are before you change anything.

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u/janek_ferrari5 points·6 months ago

interval stretching is the most commonly described approach here

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u/zeynep_ndiaye33 points·6 months ago

Do you have a written baseline from before you started changing anything?

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u/customs_seizure_sid7 points·6 months ago

Interval stretching lowers the trough concentration while keeping the dose; dose reduction lowers the level while keeping the rhythm. They are different interventions with different subjective profiles.

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u/chain_confirm_cpayments23 points·6 months ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/coa_janitormod · c/coa5 points·6 months ago

stretching to ten days then twelve is the pattern people report

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u/camila_marchand2 points·6 months ago

the habits are what has to carry it afterwards

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u/vial_math_verasyringe math3 points·6 months ago

That is a pause rather than a stop, and the plans for the two are not the same.

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u/cormac_erdogan20 points·6 months ago

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

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u/ines_boateng15 points·6 months ago

Stopped for cost reasons. Appetite came back at about week 14, well before the scale moved, exactly as this board said it would.

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u/injection_site_iris8 points·6 months ago

Small fix — you have described interval stretching and called it a taper. The exposure profiles differ.

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u/arne_restrepo5 points·6 months ago

regain is the expected outcome and framing it as failure helps nobody

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u/lina_adebayoOP4 points·6 months ago

regain is the expected outcome and framing it as failure helps nobody

This is the sentence that reframes the whole board. Appetite first, scale later.

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u/priya_guerrero13 points·6 months ago·edited

Disagree with the framing. Regain is the documented outcome after discontinuation; calling it a personal failure is both wrong and corrosive.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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