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c/sideeffects·posted 2 years ago by u/usp_appendix

[Question] heart rate — what am I missing here

Question Clean Column ×3 Receipts ×2 Long Haul ×1

heart rate — what am I missing here, and I want the answer with the reasoning attached rather than just the conclusion.

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

That is everything I have. The rest is opinion and I have tried to keep it out.

6,976 up / 2,091 down77% upvoted33 commentsid n5khoo27 May 2024

33 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/ferritin_low681 points·2 years ago

On buying things to fix side effects, which I did extensively and would not do again.

The interventions that changed anything for me were all behavioural and free: smaller meals, eating slower, stopping food a few hours before sleep, more fibre and considerably more water. The things I bought did nothing I could detect, and I was motivated to detect something.

The other lever, which people forget, is time at dose. Holding rather than stepping is a legitimate plan and it fixed my tolerance where nothing else did.

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u/adaeze_brandt408 points·2 years ago

How long after a step up did this start?

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u/constipation_clubside effects243 points·2 years ago·edited

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/usp_appendixcompendial513 points·2 years ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 40 probably does not, and that is worth saying to a clinician rather than to us.

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u/usp_appendixOPcompendial602 points·2 years ago

Is it every week or did it start at a particular dose?

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u/line_petrov479 points·2 years ago

sulphur burps are unpleasant and they are not dangerous

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u/yannick_barros106 points·2 years ago

a rough fortnight at each step is normal, a rough three months is not

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u/placebo_arm_pam87 points·2 years ago

fatigue plus low intake is usually just low intake

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u/neha_rahimi102 points·2 years ago

fatigue plus low intake is usually just low intake

placebo_arm_pam is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/peptidemeter_pat220 points·2 years ago

the first fortnight after a step is the worst of it, then it settles

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u/marit_coelho167 points·2 years ago

the first fortnight after a step is the worst of it, then it settles

This is the shape almost everybody here describes, and it is the single most reassuring thing in the thread.

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u/rafael_ostergaard167 points·2 years ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/nabila_ogunleye0 points·2 years ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/ferritin_low1 point·2 years ago

write down when it starts and stops, the pattern is the useful part

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u/yannick_barros301 points·2 years ago

eating slower does more than most of the supplements people recommend

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u/gentle_correctionMOD185 points·2 years ago·edited

This one needs a clinician rather than a comment section, and we have said so in the thread rather than removing it.

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u/usp_appendixOPcompendial96 points·2 years ago

How long has it been going on for now?

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u/naomi_erdogan33 points·2 years ago

This. A bad fortnight after a step is expected. A bad quarter is a reason to talk to somebody who knows your history.

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u/usp_appendixOPcompendial17 points·2 years ago

Which day of the week relative to the shot does it hit?

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u/enzo_danquah20 points·2 years ago

smaller meals, earlier, is the boring advice that works

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u/kavya_kravchenko63 points·2 years ago

if it is severe or persistent that is a clinician question, not a board question

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u/sequence_checkerresearch peptides50 points·2 years ago

That reads like advice, and none of us can give it. Describe what you did, not what somebody else should do.

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u/iman_falk143 points·2 years ago

reflux at night, try not eating in the three hours before bed

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u/liv_vukovic129 points·2 years ago

holding a dose an extra month is a legitimate answer to bad tolerance

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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