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c/sideeffects·posted 10 months ago by u/elin_lindqvist

[Discussion] we are measuring gallbladder at the wrong time and calling it noise

Discussion Sourced ×8 Receipts ×1 Long Haul ×3

Thinking out loud about this: we are measuring gallbladder at the wrong time and calling it noise.

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

Reflux was the one that got me. Stopped eating in the three hours before bed and it went from nightly to almost never.

Held the dose for an extra six weeks instead of stepping. The nausea settled and I lost the same amount anyway.

If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.

3,362 up / 329 down91% upvoted37 commentsid f4ueou29 Sep 2025

37 comments

20 in this archive, depth 4

best — the order this archive was captured in

u/ferritin_low386 points·10 months ago·edited

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/usp_appendixcompendial320 points·10 months ago

The pattern almost everyone here describes, written out once so it can be linked.

A step up is followed by a rough window — commonly constipation arriving the day after the shot and easing by day four, worst in the first fortnight, then flattening out. At a stable dose it usually settles further. Constipation and fatigue tend to track intake and fluid rather than the compound directly, which is why the unglamorous answers work.

What sits outside that pattern: severe pain, symptoms that appear from nowhere weeks into a stable dose, or anything getting worse rather than better over a month. None of that is a board question and none of us can answer it for you.

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u/elin_lindqvistOP221 points·10 months ago

Mine settled at week 70 and has not come back since, across two more steps.

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u/nabila_ogunleye150 points·10 months ago

reflux at night, try not eating in the three hours before bed

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u/tomas_lehtinen-27 points·10 months ago

Disagree. Severe abdominal pain is not on the list of things to wait out, and this board should not be treating it as one.

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u/yannick_barros106 points·10 months ago

Bought four different things to fix my reflux. What actually worked was eating half as fast.

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u/vendorinvestigate_vic124 points·10 months ago

fibre and water before you buy anything to fix it

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u/liv_vukovic94 points·10 months ago

Nobody warned me about fatigue and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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u/emil_barros57 points·10 months ago

Nobody warned me about fatigue and I would have liked the warning.

Disagreeing with this one line: that symptom is not on the wait-and-see list and should not be posted as though it is.

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u/milan_villalobos13 points·10 months ago

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

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u/chidi_abubakar56 points·10 months ago

if it is severe or persistent that is a clinician question, not a board question

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u/rania_diallo41 points·10 months ago·edited

muscle cramps for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

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u/diego_sorensen27 points·10 months ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/sanne_laurent14 points·10 months ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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u/wrong_network_w3 points·10 months ago

a rough fortnight at each step is normal, a rough three months is not

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u/naomi_erdogan2 points·10 months ago

holding a dose an extra month is a legitimate answer to bad tolerance

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u/fabio_nkemelu7 points·10 months ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

Adding to this — holding the dose rather than stepping is the option people forget they have.

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u/liv_vukovic7 points·10 months ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/milan_villalobos20 points·10 months ago

Are you eating in the couple of hours before you sleep?

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u/elin_lindqvistOP8 points·10 months ago

Has anything else changed in the same window?

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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