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nausea day 2 post-injection like clockwork, week 14, does it ever stop

Management Clean Column ×4 Slow Clap ×3

nausea day 2 post-injection like clockwork, week 14, does it ever stop. Posting the boring middle of the process, because the internet is full of the start and the end and nothing else.

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

That is everything I have. The rest is opinion and I have tried to keep it out.

1,180 up / 156 down88% upvoted43 commentsid 1c4pyu26 Jul 2026

43 comments

15 in this archive, depth 5

best — the order this archive was captured in

u/blunt_coldbox_2024-22 points·3 days ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/rekha_mbeki1 point·3 days ago

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

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u/lina_dziedzic125 points·2 days ago

the fatigue that arrives at week 86 out of nowhere is usually something else

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u/plain_titration_2024101 points·2 days ago

if it is severe or persistent that is a clinician question, not a board question

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u/ayesha_erdogan74 points·1 days ago

Yes — the day-two-to-day-four window is so consistent across this board that it is almost diagnostic.

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[removed]70 points·2 days ago

[removed by moderator]

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u/graph_it_gary29 points·1 days ago

a rough fortnight at each step is normal, a rough three months is not

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u/plain_titration_2024OP12 points·1 days ago

Mine settled at week 81 and has not come back since, across two more steps.

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u/vendorinvestigate_vic7 points·1 days ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/thermal_mass_tom62 points·1 days ago

Severe, or unpleasant? They are genuinely different questions and the answers diverge.

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u/slow_logbook_ftw79 points·1 days ago·edited

How long after a step up did this start?

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u/aleksi_lehtinen22 points·1 days ago

smaller meals, earlier, is the boring advice that works

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u/neha_rahimi8 points·1 days ago

sulphur burps are unpleasant and they are not dangerous

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u/adnan_karlsen98 points·3 days ago

eating slower does more than most of the supplements people recommend

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u/halima_mbeki69 points·2 days ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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