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c/semaglutide·submitted 6 months ago by u/marta_trevino

titration is the most under-discussed thing on this board

Discussionbranch of 8 comments

titration is the most under-discussed thing on this board. Making the case below, and I expect to lose some of it in the comments. The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does. Steady state after a dose change takes…

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8 comments, started 6 months ago
u/rina_bergstrom19 points·6 months ago

the appetite signal and the scale move on different clocks

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u/leila_vasquez5 points·6 months ago

Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.

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u/marta_trevinoOP2 points·6 months ago

Are you measuring anything other than weight? Waist is usually the one that keeps moving.

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u/tomas_kimani1 point·6 months ago

the ladder exists because the gut needs the time, not because the pharmacy likes paperwork

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u/leila_silva1 point·6 months ago

2.4 is a ceiling, not a target

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u/diego_sorensen1 point·6 months ago

the scale is the least sensitive instrument you own

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u/dead_space_doug1 point·6 months ago

nausea that arrives on day two and fades by day four is the standard shape

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