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c/semaglutide·posted 12 days ago by u/camila_mensa

why does everyone say week 4 is the wall

Discussion Well Actually ×2

Here it is: why does everyone say week 4 is the wall. One person, one log, no control group, so read it accordingly.

The mental model that finally made this click for me: there are two curves, and people watch the wrong one.

The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.

Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.

What I would tell week-one me, in order of how much time it would have saved.

One: the first month is a tolerance check. You are finding out whether you can take this, not how much you will lose. Two: write down the dose, the day and the waist measurement. Three: a stall of under six weeks is weather, not climate. Four: reflux that arrives the day after the shot and fades by day four is the ordinary pattern and it usually settles at a stable dose.

None of that is advice about what you should do. It is the shape of the thing, which nobody explained to me and which the wiki explains better than I just did.

I will update this if the picture changes rather than quietly leaving it up.

2,178 up / 1,903 down53% upvoted22 commentsid 1f5vkz18 Jul 2026

22 comments

16 in this archive, depth 4

best — the order this archive was captured in

u/greta_perrin36 points·11 days ago

Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the early fullness usually fades at a stable dose.

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u/iman_falk24 points·12 days ago

Week 38: 13kg down, muscle cramps basically gone since about week 2, and the honest headline is that nothing dramatic happened. It was boring and it worked.

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[deleted]18 points·12 days ago

[deleted]

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u/vikram_mbeki7 points·12 days ago

Kept a log from week one and the single most useful column turned out to be waist, not weight.

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u/careful_gradient_again19 points·11 days ago

the first four weeks are a tolerance check, not a weight-loss phase

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u/ines_castellanos13 points·11 days ago

STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure

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u/dose_creep_dan13 points·11 days ago

the first four weeks are a tolerance check, not a weight-loss phase

This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.

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u/niels_lindqvist8 points·11 days ago

This is the part I would underline for anyone skimming.

Disagree with this specific line. A pause at 0.25mg is not evidence that 0.25mg has stopped working.

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u/aleksi_grimaldi16 points·11 days ago

the appetite signal and the scale move on different clocks

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u/yara_boateng-36 points·11 days ago

do not chase somebody else’s titration schedule, they are not you

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u/camila_mensaOP1 point·11 days ago

Correcting myself from earlier in the thread: I said week 9 and it was week 13. Same shape, wrong number.

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u/helga_vermeulen1 point·11 days ago

stalling at 0.5mg is information, not a verdict

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u/bilal_osei-46 points·11 days ago

nausea that arrives on day two and fades by day four is the standard shape

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u/quiet_moderatormod8 points·10 days ago

Same injection day each week, or has it drifted?

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u/leila_vasquez6 points·10 days ago

Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.

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u/camila_mensa7 points·10 days ago

Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.

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