u/dexa_twice_yearly

Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.

Not convinced comparison helps here. The people posting the fastest results are the tail of a distribution, not the middle.

Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.

Appetite change and weight change are different measurements on different timescales. The first is usually noticed first and the second lags it.

What timeframe is that over?

if 7.5 is working, 10 is not automatically better

Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.

The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 51 is not a fair reading.

Agreed that goal weights picked at the start are guesses. Mine was, and I revised it twice.

That is an escalation schedule for an unapproved compound and this board does not host those.

hold the dose that works, the ladder is not a leaderboard

Do sulphur burps follow the day after the shot, or is it spread across the week?

Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.

Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.

Switching from semaglutide, since three people asked in this thread alone.

There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.

None of that is a recommendation. It is what the threads say, and the threads are not a clinic.

no question is too basic here, that is the entire point of the board

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

Right — the volume you add is the only variable you control here, and the cake does not change it meaningfully.

Did the maths give you a whole number of units, or a fraction?

Right, and the trial titration was slow for reasons that are visible in the tolerability tables.

read the wiki first, then ask anyway

This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.

What is written on the vial right now?

Small fix — a U-100 syringe is 100 units per mL. If yours is marked differently it is not U-100 and the whole calculation changes.

Bacteriostatic water contains benzyl alcohol as a preservative, which is what makes repeated entry into the same vial reasonable. Plain sterile water has no preservative.

How to make a DEXA comparison mean anything.

Same machine, same clinic, same protocol. Same hydration and fasting state, as far as you can manage. At least three to four months apart, because the measurement error is large relative to short-term change. Three scans rather than two, because the first pair cannot distinguish a trend from noise.

Do less than that and you have two numbers with an offset of unknown size, which people then react to by rebuilding a training programme. The free alternative — a few tracked lifts and a monthly waist measurement — is directionally informative, costs nothing, and is far harder to over-interpret.

Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.

Wrote down one non-scale thing every week. Reading a year of those back was more affecting than any number.

ask the dumb question, three other people are searching for it

Agreed — week two with nothing on the scale is so common it should be in the sidebar. It probably is.

I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your nausea pattern is a guess.

2.5 is the starter dose and it is not meant to be the dose that works

progress is not linear and nobody’s is

Nothing here is a training or nutrition prescription. Targets and programmes are matters for somebody who knows your history and your training background.

Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions for a person.

Same experience with the appetite effect being flatter across the week rather than front-loaded.

Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.

What step are you on and how long have you been there?

more water is not more drug, it is the same drug in a bigger volume

Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.