[Results] 66 weeks on 15mg, full numbers, ask me anything boring
Six-word version is the title — 66 weeks on 15mg, full numbers, ask me anything boring — and the rest is context.
66 weeks and 15mg. Those are measured, not estimated, and not rounded up in my favour.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.
best — the order this archive was captured in
Week 32 was the first time the scale moved after a five-week stall. I changed nothing in that window.
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Which week did the appetite change actually land for you?
2.5 is the starter dose and it is not meant to be the dose that works
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
the four-week step schedule is the label, not folklore
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
the muscle cramps profile is genuinely gentler than people expect coming from sema
switching from sema is not a dose conversion, there is no clean equivalence
if 7.5 is working, 10 is not automatically better
Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.
week 6 is early to draw any conclusion at all
Did you come to this from sema, and if so how long was the gap?
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
if 7.5 is working, 10 is not automatically better
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Came off sema and onto tirz with a two-week gap.
Saving this one. It is the clearest statement of the stall problem I have read here.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
Right.
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
zepbound and mounjaro are the same compound with different labels
Not sure that follows. You went up a step and changed your training in the same fortnight.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
- 1if 7.5 is working, 10 is not automatically better12 comments in this branch · started by u/emil_barros