925
[Trial Data] phase 2 biopsy endpoints, and what "resolution" means
Thinking out loud about this: phase 2 biopsy endpoints, and what "resolution" means. The honest evidence position, written out so this board does not drift. Phase 2…
endpoint
Every GLP Research Hub submission tagged to endpoint, ranked by score. Discussed in 1 community.
Communities covering this
915
[Readout] REDEFINE 1 and what CagriSema actually adds over sema alone
Posting this as a discussion rather than a claim: REDEFINE 1 and what CagriSema actually adds over sema alone. Compared myself to a trial mean for about six months…
904
[Meta] the FLOW rule is doing its job and people should stop complaining
the FLOW rule is doing its job and people should stop complaining. This affects how posts get sorted and removed, so it belongs in the open. The discontinuation numbers…
854
[Trial Data] STEP 1 vs SURMOUNT-1 side by side, with the caveats
Posting this as a discussion rather than a claim: STEP 1 vs SURMOUNT-1 side by side, with the caveats. Compared myself to a trial mean for about six months before…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards731
[Stats] relative risk reduction sells papers, absolute risk reduction makes decisions
relative risk reduction sells papers, absolute risk reduction makes decisions. It is the sort of thing everyone half-believes and nobody writes down. The…
722
SURPASS — 24 things I got wrong before I got it right
Posting this as a discussion rather than a claim: SURPASS — 24 things I got wrong before I got it right. Compared myself to a trial mean for about six months before…
716
[Meta] the FLOW rule is doing its job and people should stop complaining
the FLOW rule is doing its job and people should stop complaining. Nothing about this affects the ranking maths, before anyone asks. Started keeping the trial…
685
[Press Release] new phase 3 numbers, no publication yet, calm down
new phase 3 numbers, no publication yet, calm down. It is the sort of thing everyone half-believes and nobody writes down. A confidence interval is the range of effects…
660
the STEP question that gets asked weekly, answered properly
the STEP question that gets asked weekly, answered properly. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix tables…
643
[PSA] STEP is not what most of this community thinks it is
STEP is not what most of this community thinks it is — with the reasoning, because a rule without a reason gets ignored. Started keeping the trial identifiers straight…
637
the STEP thing finally clicked for me and I want to write it down
the STEP thing finally clicked for me and I want to write it down. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix…
573
[Discussion] TRIUMPH is doing more work than we give it credit for
TRIUMPH is doing more work than we give it credit for. It is the sort of thing everyone half-believes and nobody writes down. Spent an evening with the appendix tables…
548
[Question] how do you actually verify SURPASS
Slightly embarrassed to be asking this, but: how do you actually verify SURPASS. Argued for a week about a result and then read the limitations section, which conceded…
535
SURPASS — 16 things I got wrong before I got it right
SURPASS — 16 things I got wrong before I got it right. It is the sort of thing everyone half-believes and nobody writes down. Spent an evening with the appendix tables…
520
[Stats] the placebo arm lost weight too. always ask by how much.
the placebo arm lost weight too. always ask by how much — a position I have arrived at slowly and would like tested. Why comparing across trials almost never works,…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net489
[Stats] number needed to treat, or i am not interested
number needed to treat, or i am not interested, and I am aware this is a minority view on this board. Read a press release and the publication three months apart. The…
479
how much of what we believe about endpoint actually comes from FLOW threads
Question in the title, detail here: how much of what we believe about endpoint actually comes from FLOW threads. Went looking for the registered protocol to see whether…
438
[Meta] the FLOW rule is doing its job and people should stop complaining
the FLOW rule is doing its job and people should stop complaining. Nothing about this affects the ranking maths, before anyone asks. On means, which this board treats…
417
[Discussion] the endpoint advice in here is 3 years out of date
The title is the argument: the endpoint advice in here is 3 years out of date. Here is the rest of it. To save the first four comments: 3 years. On means, which this…
414
[Question] how do you actually verify SURPASS
how do you actually verify SURPASS — that is what I am asking, and I have already read the wiki twice. Started keeping the trial identifiers straight in a note file…
390
[PSA] write the concentration on the vial. that is the whole post.
The one-line version is the title: write the concentration on the vial. that is the whole post. The rest is why. Intention-to-treat analyses everybody randomised…
363
watch where the curves separate, not just whether they do
Posting this as a discussion rather than a claim: watch where the curves separate, not just whether they do. Relative risk reduction without the baseline rate is…
336
the STEP thing finally clicked for me and I want to write it down
the STEP thing finally clicked for me and I want to write it down. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix…
330
why does nobody talk about SELECT
Asking properly rather than in a comment on somebody else’s thread: why does nobody talk about SELECT. Compared myself to a trial mean for about six months before…
320
how much of what we believe about endpoint actually comes from SURPASS threads
how much of what we believe about endpoint actually comes from SURPASS threads. I am not trying to be the "source?" guy. I would just like a source. Read a press…