endpoint

why does nobody talk about SELECT. Searched first, found three threads that contradict each other, hence the post. Spent an evening with the appendix tables and found…

how much of what we believe about endpoint actually comes from TRIUMPH threads. I would rather ask a basic question now than get this wrong quietly for two months. A…

SURPASS — 12 things I got wrong before I got it right — a position I have arrived at slowly and would like tested. Relative risk reduction without the baseline rate is…

someone explain FLOW to me like I have not read a paper in years — that is what I am asking, and I have already read the wiki twice. Started keeping the trial…

the endpoint advice in here is 3 years out of date. It is the sort of thing everyone half-believes and nobody writes down. 3 years. Those are measured, not estimated,…

The title is the whole question — help me understand SURMOUNT, I have read the wiki twice — but here is why I am asking. Discontinuation rates are a tolerability…

endpoint — what am I missing here. I would rather ask a basic question now than get this wrong quietly for two months. Spent an evening with the appendix tables and…

how do you actually verify SURPASS. I would rather ask a basic question now than get this wrong quietly for two months. A confidence interval is the range of effects…

TRIUMPH is doing more work than we give it credit for. Making the case below, and I expect to lose some of it in the comments. Argued for a week about a result and then…

someone explain FLOW to me like I have not read a paper in years. Searched first, found three threads that contradict each other, hence the post. The discontinuation…

the STEP question that gets asked weekly, answered properly. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix tables…

Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about endpoint actually comes from SURMOUNT threads. Compared myself to…

The title is the whole question — does SELECT actually matter or is it forum lore at this point — but here is why I am asking. Went looking for the registered protocol…

SURPASS — 6 things I got wrong before I got it right. It is the sort of thing everyone half-believes and nobody writes down. Spent an evening with the appendix tables…

how much of what we believe about endpoint actually comes from SURMOUNT threads. I am not trying to be the "source?" guy. I would just like a source. How to read one of…

how much of what we believe about endpoint actually comes from STEP threads. I would rather ask a basic question now than get this wrong quietly for two months. Spent…

Putting this to the board: the FLOW rule is doing its job and people should stop complaining. Why comparing across trials almost never works, with the specific failure…

SELECT: what the trials say vs what this community says — a position I have arrived at slowly and would like tested. Why comparing across trials almost never works,…

Trying to get a straight answer on this: can we stop arguing about TRIUMPH until somebody posts a number. Compared myself to a trial mean for about six months before…

SURPASS — 14 things I got wrong before I got it right. Making the case below, and I expect to lose some of it in the comments. Quoted a figure here confidently, got…

The title is the argument: SELECT: what the trials say vs what this community says. Here is the rest of it. Intention-to-treat analyses everybody randomised regardless…

how much of what we believe about endpoint actually comes from SELECT threads — that is what I am asking, and I have already read the wiki twice. On means, which this…

SURPASS — 22 things I got wrong before I got it right. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix tables and…

Something I keep coming back to: ATTAIN-1 — an oral pill with no food restrictions is a bigger deal than the % suggests. Quoted a figure here confidently, got asked…

proposal — a flair for FLOW posts. Nothing about this affects the ranking maths, before anyone asks. The registered protocol is public. Comparing the registered primary…