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c/trialwatch·submitted 1 year ago by u/cloudy_vial_carol

SURPASS — 15 things I got wrong before I got it right

Paperbranch of 7 comments

The title is the argument: SURPASS — 15 things I got wrong before I got it right. Here is the rest of it. Discontinuation rates are a tolerability result. A trial with a strong efficacy number and heavy discontinuation is telling you two things and people only quote one. The registered protocol is public. Comparing…

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7 comments, started 1 year ago
u/hamza_zielinski30 points·1 year ago

Read a press release and the publication three months apart. The hedging in the second one was substantial.

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u/rina_bergstrom41 points·1 year ago

read the endpoint before you read the headline

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u/nordic_pricing25 points·1 year ago

read the endpoint before you read the headline

Disagreeing with this line: that is a relative reduction and the absolute numbers are considerably less dramatic.

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u/ahmed_iyer10 points·1 year ago

a mean is not a promise

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u/adaeze_cabrera16 points·1 year ago

Careful with that mean. The distribution around it was wide enough that it describes very few individual participants.

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u/milan_mensah4 points·1 year ago

a press release is not a publication

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