c/trialwatch · created 4 Nov 2023
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix.
relative risk reduction sells papers, absolute risk reduction makes decisions. It is the sort of thing everyone half-believes and nobody writes down. The…
SURMOUNT-4 withdrawal arm, read the appendix not the abstract. Change my mind, genuinely — I have no stake in being right about this. Started keeping the trial…
The title is the argument: FLOW got published and nobody in here is talking about eGFR slope. Here is the rest of it. Intention-to-treat analyses everybody randomised…
SELECT: MACE HR 0.80, and the absolute numbers people skip — a position I have arrived at slowly and would like tested. Compared myself to a trial mean for about six…
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standardsFLOW (Perkovic et al., N Engl J Med , 2024) reported a hazard ratio of 0.76 for the composite kidney endpoint in people with type 2 diabetes and chronic kidney disease.…
Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.
Independent testing plus vendor-level trend data. Community-funded, unaffiliated.
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