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[Discussion] FFMI not weight, or you will celebrate losing muscle
Posting this as a discussion rather than a claim: FFMI not weight, or you will celebrate losing muscle. Strength retention is an imperfect but free longitudinal proxy:…
u/hamza_zielinski
Contributes reviews on supplier material. Based in Osijek.
member · joined 16 Jul 2025
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comment on FLOW got published and nobody in here is talking about eGFR slope in c/trialwatch · 1 points · 1 days ago
FLOW was kidney outcomes and it is the one nobody quotes
comment on [Stats] relative risk reduction sells papers, absolute risk reduction makes decisions in c/trialwatch · 33 points · 4 days ago
Relative risk reduction without the baseline rate is uninterpretable. A large relative reduction on a small absolute risk is a small absolute benefit.
comment on [Discussion] FFMI not weight, or you will celebrate losing muscle in c/glp1muscle · 8 points · 9 days ago
That protein figure is grams per day, not grams per kilogram. Different claim entirely.
comment on [Data] BIA vs DEXA on the same day, 6% apart, pick a method and stay with it in c/glp1muscle · -9 points · 11 days ago
protein intake gets harder exactly when appetite drops
comment on [Stats] number needed to treat, or i am not interested in c/trialwatch · 1 points · 19 days ago
That is the 68-week readout, not the 72-week one. Different trial, different duration.
comment on [Discussion] protein is doing more work than we give it credit for in c/glp1muscle · 23 points · 1 months ago
Same DEXA machine both times?
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[Discussion] protein is doing more work than we give it credit for
Posting this as a discussion rather than a claim: protein is doing more work than we give it credit for. How to make a DEXA comparison mean anything. Same machine, same…
comment on [PSA] STEP is not what most of this community thinks it is in c/trialwatch · 7 points · 1 months ago
What was the comparator?
comment on [Results] 48 weeks, 18kg, and DEXA was the hard part in c/glp1muscle · 1 points · 2 months ago
lean mass loss during weight loss is expected, the question is how much
comment on how much of what we believe about FFMI actually comes from resistance training threads in c/glp1muscle · -22 points · 3 months ago
How many weeks between the two scans?
comment on how much of what we believe about endpoint actually comes from hazard ratio threads in c/trialwatch · 243 points · 4 months ago
The registered protocol is public. Comparing the registered primary endpoint with the reported one is a two-minute check and it is how outcome switching gets caught.
comment on SURPASS — 14 things I got wrong before I got it right in c/trialwatch · 80 points · 6 months ago
registry entry, protocol, publication — three different documents
comment on three years of protein threads, summarised so you do not have to read them in c/glp1muscle · 0 points · 7 months ago
Correction: those scans are from different machines, and the difference you are describing is within the measurement error.
comment on [Question] how do you actually verify SURPASS in c/trialwatch · 26 points · 10 months ago
Quoted a figure here confidently, got asked whether it was ITT, went and checked, and it was not. Learned something.
comment on SURPASS — 15 things I got wrong before I got it right in c/trialwatch · 30 points · 1 year ago
Read a press release and the publication three months apart. The hedging in the second one was substantial.
comment on hazard ratio is the most under-discussed thing on this board in c/trialwatch · 0 points · 1 year ago
Is that intention-to-treat or completers?
Adding the check nobody runs — the registered protocol is public and takes two minutes to compare.
comment on does protein actually matter or is it forum lore at this point in c/glp1muscle · 11 points · 1 year ago
Tracked grip strength and three lifts monthly. Cheaper than scanning and directionally the same answer.
comment on reading resistance training threads from 2024 and half of it aged badly in c/glp1muscle · 14 points · 1 year ago
grip strength and lift numbers are cheap longitudinal markers
Agreed — and same machine, same conditions, or the two scans are not comparable.
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SURPASS — 4 things I got wrong before I got it right
SURPASS — 4 things I got wrong before I got it right. Change my mind, genuinely — I have no stake in being right about this. The registered protocol is public.…
comment on hazard ratio is the most under-discussed thing on this board in c/trialwatch · 250 points · 1 year ago
a press release is not a publication
This is the distinction that would end about half the arguments on this board.
comment on hazard ratio is the most under-discussed thing on this board in c/trialwatch · 169 points · 1 year ago
This. Intention-to-treat versus completer analysis routinely moves the headline by several points.
comment on [PSA] STEP is not what most of this community thinks it is in c/trialwatch · 39 points · 1 year ago
A confidence interval is the range of effects compatible with the data. Two trials with overlapping intervals have not disagreed, whatever their point estimates look like next to each other.
comment on SURPASS — 12 things I got wrong before I got it right in c/trialwatch · 37 points · 2 years ago
Is that intention-to-treat or completers?
comment on SURPASS — 9 things I got wrong before I got it right in c/trialwatch · 184 points · 2 years ago
Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about.