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c/tapering·submitted 1 year ago by u/naomi_ekstrom

switched from 0.5mg to 1.0mg and early fullness got better, not worse

Regainbranch of 9 comments

switched from 0.5mg to 1.0mg and early fullness got better, not worse. Not a hot take, just something I have not seen said plainly here. 0.5mg and 1.0mg. Those are measured, not estimated, and not rounded up in my favour. A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change…

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9 comments, started 1 year ago
u/source_or_silence49 points·1 year ago

Has appetite changed yet, independent of the scale?

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u/maintenance_mode_maxmaintenance39 points·1 year ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/chidi_vermeulen12 points·1 year ago

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

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u/patient_labslip_log10 points·1 year ago

Have you had the conversation with a clinician yet?

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u/marta_dziedzic6 points·1 year ago·edited

Have you had the conversation with a clinician yet?

Adding the one process step — write down where you are before you change anything.

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u/zeynep_villalobos2 points·1 year ago

Regained most of it over a year and spent that year assuming it was my fault. It was not; it is what the literature describes.

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u/yara_bakken1 point·1 year ago

coming back later is allowed and it is common

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u/marta_marchand4 points·1 year ago

stretching to ten days then twelve is the pattern people report

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u/hana_lehtinen2 points·1 year ago·edited

stretching to ten days then twelve is the pattern people report

Agreed — and the exposure lag means the first fortnight tells you almost nothing.

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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