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c/tapering·posted 4 months ago by u/chidi_vermeulen

13 months in and discontinuation is still the thing I get wrong

Regain

Check-in as promised in the title: 13 months in and discontinuation is still the thing I get wrong.

The relevant figures are 13 months, and they come from the same log I have kept the whole time.

Had the conversation with a clinician before stopping rather than after. Considerably easier that way round.

Stopped abruptly once and gradually once. The gradual one was easier to interpret because I could see what was changing.

Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.

177 up / 52 down77% upvoted21 commentsid 1jbtc78 Mar 2026

21 comments

12 in this archive, depth 6

best — the order this archive was captured in

u/neha_krastev29 points·4 months ago·edited

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/zeynep_villalobos18 points·4 months ago

have the conversation with a clinician before, not after

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u/chidi_vermeulenOP12 points·4 months ago

The habits are what carried it for a while. When they slipped, everything else followed, in that order.

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u/dario_stanescu8 points·4 months ago

Careful — interval stretching and dose reduction are different interventions and your post uses them interchangeably.

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u/rina_bergstrom3 points·4 months ago

Careful — interval stretching and dose reduction are different interventions and your post uses them interchangeably.

This is the sentence that reframes the whole board. Appetite first, scale later.

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u/fabio_lehtinen2 points·4 months ago·edited

Push back: that is a taper schedule aimed at another member and this board does not host those.

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u/elin_varga10 points·4 months ago

Small fix — you have described interval stretching and called it a taper. The exposure profiles differ.

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u/appeal_letter_al-33 points·4 months ago

I would not treat appetite returning as a sign of doing it wrong. It is the expected sequence.

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u/chidi_vermeulenOP1 point·4 months ago

Stretching the interval or reducing the dose?

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u/diego_szabo15 points·4 months ago

Interval stretching lowers the trough concentration while keeping the dose; dose reduction lowers the level while keeping the rhythm. They are different interventions with different subjective profiles.

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u/chidi_vermeulenOP6 points·4 months ago

What are you planning to watch for, and over what period?

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u/zeynep_weiss0 points·4 months ago

What are you planning to watch for, and over what period?

Disagreeing with this bit: stretching and reducing are different things and the post treats them as one.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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