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c/t2dglp1·posted 2 months ago by u/kasper_cabrera

[Meta] the hypoglycaemia rule is doing its job and people should stop complaining

CGM

the hypoglycaemia rule is doing its job and people should stop complaining. Nothing about this affects the ranking maths, before anyone asks.

The diabetes and obesity programmes are separate, with different populations and different primary endpoints. Reading a result across from one to the other is not a comparison.

Incretin-based agents stimulate insulin secretion in a glucose-dependent manner, which is why hypoglycaemia risk with them alone is low. Risk rises with agents that act independently of glycaemia.

Postprandial excursions typically respond earlier than fasting glucose, so the sequence people observe is not a sign that something is not working.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

254 up / 62 down80% upvoted11 commentsid 1vmp8912 May 2026

11 comments

8 in this archive, depth 3

best — the order this archive was captured in

u/marisol_moreau13 points·2 months ago

Sensor accuracy varies across wear, and readings on the first day are the least reliable. Calibration practice and compression artefacts explain many alarming single values.

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u/tomas_kimani3 points·2 months ago

Sensor accuracy varies across wear, and readings on the first day are the least reliable.

Disagreeing with this line: that endpoint is from the obesity programme and does not answer the question.

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u/cloudy_vial_carol13 points·2 months ago

What else is in the regimen?

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u/britt_abubakar9 points·2 months ago

the fasting number is the one people fixate on and it moves last

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u/osman_ferrari2 points·2 months ago

the fasting number is the one people fixate on and it moves last

britt_abubakar is right that the fasting number moves last. Knowing that in advance saves months of worry.

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u/tired_ledger_notes6 points·2 months ago

Panicked over a first-day sensor reading and rebuilt my week around it. It was the sensor.

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u/hassan_ostergaard4 points·2 months ago

Fasting or postprandial?

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[removed]3 points·2 months ago

[removed by moderator]

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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