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c/sideeffects·posted 8 months ago by u/isabela_nilsen

switched from 10mg to 12.5mg and early fullness got better, not worse

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switched from 10mg to 12.5mg and early fullness got better, not worse, and I am aware this is a minority view on this board.

10mg and 12.5mg — those are the numbers, and they are the ones I am willing to defend.

On buying things to fix side effects, which I did extensively and would not do again.

The interventions that changed anything for me were all behavioural and free: smaller meals, eating slower, stopping food a few hours before sleep, more fibre and considerably more water. The things I bought did nothing I could detect, and I was motivated to detect something.

The other lever, which people forget, is time at dose. Holding rather than stepping is a legitimate plan and it fixed my tolerance where nothing else did.

Keeping a log, and what to put in it.

One line a day: dose, day since injection, what the symptom was and how bad out of five, and roughly what you ate. Two months of that fits on one page and the pattern is obvious on paper in a way it never is in your head.

Mine showed a clean day-two-to-day-four window I had been describing as "random". Once you can see the pattern you can plan around it, and planning around it is most of the relief.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

2,365 up / 579 down80% upvoted47 commentsid g8stgq2 Nov 2025

47 comments

12 in this archive, depth 3

best — the order this archive was captured in

u/milan_villalobos200 points·8 months ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 54 probably does not, and that is worth saying to a clinician rather than to us.

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u/nabila_ogunleye-15 points·8 months ago

fatigue plus low intake is usually just low intake

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u/constipation_clubMOD102 points·8 months ago·edited

Removed the specific recommendation. Describe your own experience here; do not tell another member what to take or what dose to be on.

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u/usp_appendixcompendial39 points·8 months ago

eating slower does more than most of the supplements people recommend

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u/long_post_larry55 points·8 months ago

The pattern almost everyone here describes, written out once so it can be linked.

A step up is followed by a rough window — commonly muscle cramps arriving the day after the shot and easing by day four, worst in the first fortnight, then flattening out. At a stable dose it usually settles further. Constipation and fatigue tend to track intake and fluid rather than the compound directly, which is why the unglamorous answers work.

What sits outside that pattern: severe pain, symptoms that appear from nowhere weeks into a stable dose, or anything getting worse rather than better over a month. None of that is a board question and none of us can answer it for you.

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u/plain_titration_2024152 points·8 months ago

reflux at night, try not eating in the three hours before bed

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u/tl_dr_tina129 points·8 months ago

write down when it starts and stops, the pattern is the useful part

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u/rekha_mbeki61 points·8 months ago

Agreed. Slowing down at meals did more for my constipation than everything I bought to fix it, which was embarrassing to discover.

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u/salma_baptista85 points·8 months ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/tomas_lehtinen57 points·8 months ago

Which day of the week relative to the shot does it hit?

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u/tl_dr_tina23 points·8 months ago

Yes — the day-two-to-day-four window is so consistent across this board that it is almost diagnostic.

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u/long_post_larry5 points·8 months ago

Nobody warned me about constipation and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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