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c/sideeffects·posted 4 months ago by u/piotr_bruun

anyone else notice constipation kicking in around week 7

Management Well Actually ×4

anyone else notice constipation kicking in around week 7. Numbers below. Ask me the boring questions, they are the useful ones.

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

Sceptical readings welcome. The confident ones are the ones I distrust.

831 up / 294 down74% upvoted32 commentsid 1b1r0g4 Mar 2026

32 comments

23 in this archive, depth 6

best — the order this archive was captured in

u/ayesha_radich125 points·4 months ago·edited

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/sanne_laurent63 points·4 months ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss.

ayesha_radich is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/lina_dziedzic82 points·4 months ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/rohan_steiner88 points·4 months ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/ferritin_low59 points·4 months ago

What is intake actually looking like — fibre and water especially?

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[removed]40 points·4 months ago

[removed by moderator]

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u/hassan_castellanos30 points·4 months ago

I would be careful here. "Everyone gets this" is not true, and it makes the people who get something unusual assume they are fine when they should be asking.

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u/gentle_correctionMOD46 points·4 months ago

Removed the specific recommendation. Describe your own experience here; do not tell another member what to take or what dose to be on.

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u/hassan_castellanos22 points·4 months ago

Nobody warned me about injection-site soreness and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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u/graph_it_gary13 points·4 months ago

Disagree. Severe abdominal pain is not on the list of things to wait out, and this board should not be treating it as one.

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u/priya_weiss9 points·4 months ago

nobody warns you about how much of this is timing rather than dose

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u/piotr_bruunOP9 points·4 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/zaid_balogun5 points·4 months ago

That symptom is not the one being described upthread.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/fabio_nkemelu7 points·4 months ago

Held the dose for an extra six weeks instead of stepping. The food noise settled and I lost the same amount anyway.

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u/naomi_erdogan3 points·4 months ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/ayesha_radich2 points·4 months ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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u/liv_vukovic30 points·4 months ago

hair shedding follows the weight loss, not the drug, and it stops

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u/piotr_bruunOP23 points·4 months ago

How long has it been going on for now?

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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