stalled for 21 weeks at 2.4mg and I refuse to panic this time
Something I keep coming back to: stalled for 21 weeks at 2.4mg and I refuse to panic this time.
Since the title puts numbers in the shop window: 21 weeks and 2.4mg.
On the "everybody ends up at 2.4" claim, which comes up every few weeks.
The escalation schedule in the trials was designed to get people to a fixed study dose. Real use is not a trial. The dose that keeps your appetite quiet with side effects you can live with is the dose, and for a lot of people on this board that has been 0.5mg for a very long time.
The counter-argument, which is fair: some people genuinely do need the top of the range, and staying low out of caution costs them months. That is a conversation with someone who knows your history, not with us.
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.
best — the order this archive was captured in
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Standard reminder: no personal titration plans for other members, and no medical advice. Everything else is fine.
Standard reminder: no personal titration plans for other members, and no medical advice.
nausea_notes is describing the standard shape here and it matches the trial data better than most anecdotes do.
the first four weeks are a tolerance check, not a weight-loss phase
How long was the stall before you decided it was a stall?
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Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
stalling at 0.25mg is information, not a verdict
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
sema is weekly for a reason, the half-life does the smoothing
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
Week 33: 16kg down, food noise basically gone since about week 6, and the honest headline is that nothing dramatic happened. It was boring and it worked.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chem
Disagree with this specific line. A pause at 2.4mg is not evidence that 2.4mg has stopped working.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chem
Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.
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