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Single comment threadYou are looking at one branch of switched from 0.25mg to 1.0mg and fatigue got better, not worse — 39 comments in the full submission. View in context.
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c/semaglutide·submitted 6 months ago by u/hassan_castellanos

switched from 0.25mg to 1.0mg and fatigue got better, not worse

Resultsbranch of 7 comments

switched from 0.25mg to 1.0mg and fatigue got better, not worse. Change my mind, genuinely — I have no stake in being right about this. The numbers the title promised, since a headline without them is worthless: 0.25mg and 1.0mg. Everything below is context for those. The escalation schedule in the trials existed to…

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7 comments, started 6 months ago
u/marit_coelho1.5k points·6 months ago

Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.

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u/hassan_castellanosOP2.2k points·6 months ago·edited

if 1.0mg is working there is no prize for going up

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u/marit_coelho1.8k points·6 months ago

Minor fix — the half-life is about a week, not about a day. The rest of your point stands.

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u/ravi_sandvik641 points·6 months ago

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

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u/hassan_castellanosOP1.8k points·6 months ago

Correcting myself from earlier in the thread: I said week 12 and it was week 18. Same shape, wrong number.

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u/greta_perrin0 points·6 months ago

Correcting myself from earlier in the thread: I said week 12 and it was week 18.

Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.

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u/vikram_mbeki1.4k points·6 months ago·edited

Did protein intake change in the same window?

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