switched from 0.25mg to 1.0mg and fatigue got better, not worse
switched from 0.25mg to 1.0mg and fatigue got better, not worse. Change my mind, genuinely — I have no stake in being right about this.
The numbers the title promised, since a headline without them is worthless: 0.25mg and 1.0mg. Everything below is context for those.
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the nausea usually fades at a stable dose.
Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.
best — the order this archive was captured in
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
if 1.0mg is working there is no prize for going up
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
First month I lost almost nothing and nearly quit. Month two and three were where it all happened.
Correcting myself from earlier in the thread: I said week 12 and it was week 18. Same shape, wrong number.
Correcting myself from earlier in the thread: I said week 12 and it was week 18.
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
Did protein intake change in the same window?
Week 94: 23kg down, constipation basically gone since about week 4, and the honest headline is that nothing dramatic happened. It was boring and it worked.
[deleted]
dose day drift of a day either way is fine, the curve barely notices
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
the scale is the least sensitive instrument you own
Same. I sat at 0.5mg for three months because it was working and there was nothing to fix.
Yes. Week 29 is when almost everybody writes the "is it still working" post, and almost everybody is fine.
Agreed, and the bit people skip is that the ladder is a tolerance ladder. It is not a potency ranking.
Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.
2.4 is a ceiling, not a target
do not chase somebody else’s titration schedule, they are not you
- 1Research-use-only material is not approved for human use, so anything in…7 comments in this branch · started by u/marit_coelho
- 2Week 94: 23kg down, constipation basically gone since about week 4, and the…6 comments in this branch · started by u/rina_bergstrom