am I the only one who found semaglutide harder than the injections
am I the only one who found semaglutide harder than the injections. If this has been answered properly somewhere, link me and I will delete.
First month I lost almost nothing and nearly quit. Month two and three were where it all happened.
Sat at 0.5mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the nausea.
Week 95: 39kg down, fatigue basically gone since about week 6, and the honest headline is that nothing dramatic happened. It was boring and it worked.
Ask me anything specific. Anything general I will probably get wrong.
best — the order this archive was captured in
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.
if 1.0mg is working there is no prize for going up
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
2.4 is a ceiling, not a target
the scale is the least sensitive instrument you own
the appetite signal and the scale move on different clocks
2.4 is a ceiling, not a target
Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
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sema is weekly for a reason, the half-life does the smoothing
dose day drift of a day either way is fine, the curve barely notices
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
Not convinced. You changed the dose and the week at the same time, so you cannot attribute the change to either.
Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.
Does early fullness track the day after the shot, or is it there all week?
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
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