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c/semaglutide·posted 8 months ago by u/niels_lindqvist

nobody warned me about injection-site soreness and I would have liked the warning

Side Effects Clean Column ×5 Cold Box ×1

Thinking out loud about this: nobody warned me about injection-site soreness and I would have liked the warning.

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.

Week 55: 20kg down, early fullness basically gone since about week 8, and the honest headline is that nothing dramatic happened. It was boring and it worked.

I will update this if the picture changes rather than quietly leaving it up.

2,690 up / 339 down89% upvoted38 commentsid fwuadq6 Nov 2025

38 comments

11 in this archive, depth 4

best — the order this archive was captured in

u/marit_coelho262 points·8 months ago

Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.

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u/arne_restrepo107 points·8 months ago

Kept a log from week one and the single most useful column turned out to be waist, not weight.

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u/hassan_castellanos77 points·8 months ago

Did protein intake change in the same window?

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u/oskar_kaufmann175 points·8 months ago

My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.

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u/pavel_nkemelu49 points·8 months ago

My stall was eleven weeks.

This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.

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u/osman_ferrari21 points·8 months ago

Minor fix — the half-life is about a week, not about a day. The rest of your point stands.

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u/hassan_ostergaard8 points·8 months ago

Strongly agree on protein. It did more for my sulphur burps than any of the things I bought to fix my sulphur burps.

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u/niels_lindqvistOP13 points·8 months ago

Does injection-site soreness track the day after the shot, or is it there all week?

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u/niels_lindqvistOP0 points·8 months ago

What dose and how many weeks at it before this started?

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u/ewan_tulloch1 point·8 months ago

Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.

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u/kavya_radich129 points·8 months ago

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

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