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c/semaglutide·posted 2 years ago by u/ahmed_abubakar

how much of what we believe about Wegovy actually comes from semaglutide threads

Discussion Cold Box ×1 The Quiet One ×2 Receipts ×3

Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about Wegovy actually comes from semaglutide threads.

What I would tell week-one me, in order of how much time it would have saved.

One: the first month is a tolerance check. You are finding out whether you can take this, not how much you will lose. Two: write down the dose, the day and the waist measurement. Three: a stall of under six weeks is weather, not climate. Four: sulphur burps that arrives the day after the shot and fades by day four is the ordinary pattern and it usually settles at a stable dose.

None of that is advice about what you should do. It is the shape of the thing, which nobody explained to me and which the wiki explains better than I just did.

The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.

Kept a log from week one and the single most useful column turned out to be waist, not weight.

I will update this if the picture changes rather than quietly leaving it up.

4,198 up / 578 down88% upvoted35 commentsid 9kaqip20 Jul 2024

35 comments

7 in this archive, depth 5

best — the order this archive was captured in

u/enzo_danquah569 points·2 years ago

Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the nausea usually fades at a stable dose.

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u/anya_erdogan-2 points·2 years ago

Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.

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u/ahmed_abubakarOP1 point·2 years ago

staying at 2.4mg for an extra month is a legitimate plan

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u/bilal_osei1 point·2 years ago

Minor fix — the half-life is about a week, not about a day. The rest of your point stands.

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u/vikram_mbeki1 point·2 years ago

My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.

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u/boots_or_bust1 point·2 years ago

the ladder exists because the gut needs the time, not because the pharmacy likes paperwork

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u/slow_logbook_notes318 points·2 years ago·edited

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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