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c/semaglutide·submitted 1 months ago by u/rina_bergstrom

[Discussion] can we stop arguing about plateau until somebody posts a number

Discussionbranch of 6 comments

can we stop arguing about plateau until somebody posts a number. I am not trying to be the "source?" guy. I would just like a source. My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all. The appetite thing was the surprise. I expected to feel full. What I got was simply not…

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6 comments, started 1 months ago
u/titration_marshalMOD2 points·1 months ago

Retitled to match the body. The original promised a comparison the post does not make.

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u/alcohol_aversion1 point·1 months ago

if 0.5mg is working there is no prize for going up

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u/rina_bergstromOP0 points·1 months ago

What did week 87 look like compared with this one? The month either side is the useful comparison.

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u/endpoint_creep1 point·1 months ago

The mental model that finally made this click for me: there are two curves, and people watch the wrong one.

The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.

Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.

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u/osman_ferrari1 point·1 months ago

Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.

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u/iman_falk1 point·1 months ago

sema is weekly for a reason, the half-life does the smoothing

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