three years of 2.4mg threads, summarised so you do not have to read them
three years of 2.4mg threads, summarised so you do not have to read them. I have gone back and forth on this for months.
The numbers the title promised, since a headline without them is worthless: 2.4mg. Everything below is context for those.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Week 41: 9kg down, early fullness basically gone since about week 8, and the honest headline is that nothing dramatic happened. It was boring and it worked.
If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.
best — the order this archive was captured in
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
Standard reminder: no personal titration plans for other members, and no medical advice. Everything else is fine.
Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.
constipation made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.
Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.
sema is weekly for a reason, the half-life does the smoothing
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
do not chase somebody else’s titration schedule, they are not you
Yes. Week 7 is when almost everybody writes the "is it still working" post, and almost everybody is fine.
First month I lost almost nothing and nearly quit. Month two and three were where it all happened.
Correcting myself from earlier in the thread: I said week 4 and it was week 7. Same shape, wrong number.
the appetite signal and the scale move on different clocks
That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.
My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
How long was the stall before you decided it was a stall?
I would push back gently. Going up because the scale paused is the single most common mistake described on this board.
The mental model that finally made this click for me: there are two curves, and people watch the wrong one.
The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.
Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
- 1Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up…9 comments in this branch · started by u/chidi_demir