[Meta] the Wegovy rule is doing its job and people should stop complaining
Housekeeping: the Wegovy rule is doing its job and people should stop complaining.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Week 46: 17kg down, early fullness basically gone since about week 8, and the honest headline is that nothing dramatic happened. It was boring and it worked.
I will update this if the picture changes rather than quietly leaving it up.
best — the order this archive was captured in
Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
Strongly agree on protein. It did more for my injection-site soreness than any of the things I bought to fix my injection-site soreness.
Leaving this up. It is a check-in, it has numbers, and it is honest about being one person.
My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.
Correct, and worth adding: the trial average is an average. Half the people in it did worse than 15% and were still on the drug.
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the reflux usually fades at a stable dose.
That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
What dose and how many weeks at it before this started?
the food noise going quiet is the effect people actually describe
Correcting myself from earlier in the thread: I said week 4 and it was week 13. Same shape, wrong number.
This matches me almost exactly, right down to the muscle cramps showing up on the second day and being gone by the fourth.
Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.
Kept a log from week one and the single most useful column turned out to be waist, not weight.
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