what changed for me between month 6 and month 10
what changed for me between month 6 and month 10. I am not trying to be the "source?" guy. I would just like a source.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the reflux usually fades at a stable dose.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
What I would tell week-one me, in order of how much time it would have saved.
One: the first month is a tolerance check. You are finding out whether you can take this, not how much you will lose. Two: write down the dose, the day and the waist measurement. Three: a stall of under six weeks is weather, not climate. Four: reflux that arrives the day after the shot and fades by day four is the ordinary pattern and it usually settles at a stable dose.
None of that is advice about what you should do. It is the shape of the thing, which nobody explained to me and which the wiki explains better than I just did.
Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.
best — the order this archive was captured in
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
stalling at 1.0mg is information, not a verdict
stalling at 1.0mg is information, not a verdict
Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.
Leaving this up. It is a check-in, it has numbers, and it is honest about being one person.
Same. I sat at 0.5mg for three months because it was working and there was nothing to fix.
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Sat at 1.0mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the fatigue.
My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.
Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.
Correct, and worth adding: the trial average is an average. Half the people in it did worse than 15% and were still on the drug.
Yes — and the honest version is that most of the "it stopped working" posts turn out to be a normal fortnight of water weight.
do not chase somebody else’s titration schedule, they are not you
What dose and how many weeks at it before this started?
staying at 0.5mg for an extra month is a legitimate plan
nausea that arrives on day two and fades by day four is the standard shape
Week 66: 15kg down, injection-site soreness basically gone since about week 4, and the honest headline is that nothing dramatic happened. It was boring and it worked.
Week 66: 15kg down, injection-site soreness basically gone since about week 4, and the honest headline is that nothing dramatic happened.
Disagree with this specific line. A pause at 0.25mg is not evidence that 0.25mg has stopped working.
Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.
Dropped my injection day by two days once because of travel.
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
sema is weekly for a reason, the half-life does the smoothing
STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure
Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.
That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.
What did week 37 look like compared with this one? The month either side is the useful comparison.
Correcting myself from earlier in the thread: I said week 2 and it was week 10. Same shape, wrong number.