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why does nobody talk about MASH
why does nobody talk about MASH, and I want the answer with the reasoning attached rather than just the conclusion. What this compound is actually being developed for,…
Top submissions — page 36
Positions 876–900 of 1,000 ranked submissions.
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how much of what we believe about endpoint actually comes from TRIUMPH threads
how much of what we believe about endpoint actually comes from TRIUMPH threads. I would rather ask a basic question now than get this wrong quietly for two months. A…
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week 95 check-in — 48kg down, nausea manageable, one thing confusing me
Here it is: week 95 check-in — 48kg down, nausea manageable, one thing confusing me. One person, one log, no control group, so read it accordingly. The numbers the…
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the secretagogue question that gets asked weekly, answered properly
the secretagogue question that gets asked weekly, answered properly. Making the case below, and I expect to lose some of it in the comments. Purity methods differ by…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards2.2k
three years of API source threads, summarised so you do not have to read them
Thinking out loud about this: three years of API source threads, summarised so you do not have to read them. Potency and sterility testing on the finished preparation…
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[Discussion] we are measuring lane at the wrong time and calling it noise
we are measuring lane at the wrong time and calling it noise — a position I have arrived at slowly and would like tested. Where the time actually goes, which I got…
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the bacteriostatic water question that gets asked weekly, answered properly
the bacteriostatic water question that gets asked weekly, answered properly. Change my mind, genuinely — I have no stake in being right about this. The failure modes I…
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[Meta] the Canada rule is doing its job and people should stop complaining
Proposal, not a decision: the Canada rule is doing its job and people should stop complaining. National regulatory approval establishes that a product may be sold.…
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[Discussion] below spec is doing more work than we give it credit for
below spec is doing more work than we give it credit for. Change my mind, genuinely — I have no stake in being right about this. First result I ever posted here got…
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why does nobody talk about test results
Asking properly rather than in a comment on somebody else’s thread: why does nobody talk about test results. Tested three lots over a year rather than three vials from…
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why does nobody talk about excursion
The title is the whole question — why does nobody talk about excursion — but here is why I am asking. You cannot infer potency from a temperature record. The record…
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personal import — 17 things I got wrong before I got it right
personal import — 17 things I got wrong before I got it right, and I am aware this is a minority view on this board. The order to do things in when something is held,…
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[Discussion] we are measuring contraception at the wrong time and calling it noise
we are measuring contraception at the wrong time and calling it noise. Not a hot take, just something I have not seen said plainly here. Went looking for trial data on…
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[Discussion] state board is doing more work than we give it credit for
state board is doing more work than we give it credit for. Change my mind, genuinely — I have no stake in being right about this. Potency and sterility testing on the…
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small win: non-scale victory stopped being a problem at week 46
Check-in as promised in the title: small win: non-scale victory stopped being a problem at week 46. Stopped reading the fastest posts here for a month and my mood…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net2.2k
Spain: carrier, and what it actually costs here
The title is the argument: Spain: carrier, and what it actually costs here. Here is the rest of it. A lane is an origin, a destination, a carrier and a season. Change…
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group buy organiser vanished with 3.4k. here is the timeline
group buy organiser vanished with 3.4k. here is the timeline. It is the sort of thing everyone half-believes and nobody writes down. Kept a spreadsheet of quoted versus…
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[Discussion] we are measuring test results at the wrong time and calling it noise
Something I keep coming back to: we are measuring test results at the wrong time and calling it noise. Split one vial between Janoshik and VendorInvestigate. The two…
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three years of compounding threads, summarised so you do not have to read them
three years of compounding threads, summarised so you do not have to read them. I have gone back and forth on this for months. The two decisions that this whole board…
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regulatory is the most under-discussed thing on this board
regulatory is the most under-discussed thing on this board. Change my mind, genuinely — I have no stake in being right about this. The three questions, kept separate,…
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small win: insulin resistance stopped being a problem at week 79
small win: insulin resistance stopped being a problem at week 79. Numbers below. Ask me the boring questions, they are the useful ones. Anything involving pregnancy,…
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unpopular opinion: most of what gets said here about group buy is guesswork
unpopular opinion: most of what gets said here about group buy is guesswork — a position I have arrived at slowly and would like tested. The directory deliberately…
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SURPASS — 12 things I got wrong before I got it right
SURPASS — 12 things I got wrong before I got it right — a position I have arrived at slowly and would like tested. Relative risk reduction without the baseline rate is…
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[Discussion] the appetite advice in here is 3 years out of date
the appetite advice in here is 3 years out of date. Change my mind, genuinely — I have no stake in being right about this. 3 years. Those are measured, not estimated,…
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[Meta] proposal — a flair for transit time posts
Putting this to the board: proposal — a flair for transit time posts. Where the time actually goes, which I got wrong for two years. Total transit is first mile,…