TRIUMPH

how do you actually verify glucagon, and I want the answer with the reasoning attached rather than just the conclusion. Where the evidence actually stands, since every…

SURPASS — 14 things I got wrong before I got it right. Making the case below, and I expect to lose some of it in the comments. Quoted a figure here confidently, got…

The title is the argument: SELECT: what the trials say vs what this community says. Here is the rest of it. Intention-to-treat analyses everybody randomised regardless…

how much of what we believe about endpoint actually comes from SELECT threads — that is what I am asking, and I have already read the wiki twice. On means, which this…

stalled for 12 weeks at 10mg and I refuse to panic this time. It is the sort of thing everyone half-believes and nobody writes down. 12 weeks and 10mg — those are the…

is it normal to get sulphur burps at week 87. Full detail below, and I have tried to keep the editorialising out of it. Stopped at a low step because there was no…

went too fast on reta and my resting HR told me before i noticed. Change my mind, genuinely — I have no stake in being right about this. Read the phase 2 paper twice…

SURPASS — 22 things I got wrong before I got it right. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix tables and…

three years of retatrutide threads, summarised so you do not have to read them. It is the sort of thing everyone half-believes and nobody writes down. Glucagon receptor…

Thinking out loud about this: stalled for 7 weeks at 10mg and I refuse to panic this time. 7 weeks and 10mg — those are the numbers, and they are the ones I am willing…

anyone else notice triple agonist kicking in around week 65. Numbers below. Ask me the boring questions, they are the useful ones. Kept a log specifically because there…

Something I keep coming back to: ATTAIN-1 — an oral pill with no food restrictions is a bigger deal than the % suggests. Quoted a figure here confidently, got asked…

the glucagon arm is why the appetite effect feels different — a position I have arrived at slowly and would like tested. Watched heart rate on a wearable across twelve…

proposal — a flair for FLOW posts. Nothing about this affects the ranking maths, before anyone asks. The registered protocol is public. Comparing the registered primary…

is it normal to get muscle cramps at week 85. Same spreadsheet I have been keeping since the start, nothing retrofitted. Phase 2 estimates effect and finds a dose…

Posting this as a discussion rather than a claim: REDEFINE 1 and what CagriSema actually adds over sema alone. Compared myself to a trial mean for about six months…

the FLOW rule is doing its job and people should stop complaining. This affects how posts get sorted and removed, so it belongs in the open. The discontinuation numbers…

glucagon is doing more work than we give it credit for. It is the sort of thing everyone half-believes and nobody writes down. Glucagon receptor agonism is associated…

we are measuring TRIUMPH at the wrong time and calling it noise. Making the case below, and I expect to lose some of it in the comments. The constipation profile felt…

stalled for 11 weeks at 12.5mg and I refuse to panic this time, and I am aware this is a minority view on this board. The relevant figures are 11 weeks and 12.5mg, and…

week 32 check-in — 14kg down, nausea manageable, one thing confusing me, and the part I actually want to talk about is at the bottom. Numbers, in the order they matter:…

Posting this as a discussion rather than a claim: STEP 1 vs SURMOUNT-1 side by side, with the caveats. Compared myself to a trial mean for about six months before…

Posting this as a discussion rather than a claim: the TRIUMPH advice in here is 2 years out of date. Figures up front so nobody has to dig: 2 years. Sent a vial to…

Short version of the title, which is already short: ERP reta — PeptideMeter came back 98.9% against a claimed 98.0%. Longer version underneath. Figures up front so…

relative risk reduction sells papers, absolute risk reduction makes decisions. It is the sort of thing everyone half-believes and nobody writes down. The…