the glucagon arm is why the appetite effect feels different
the glucagon arm is why the appetite effect feels different — a position I have arrived at slowly and would like tested.
Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.
The thing that surprised me was how much of the discussion here is inference rather than measurement.
Kept a log specifically because there is so little published. It is one person and it is not data.
Ask me anything specific. Anything general I will probably get wrong.
best — the order this archive was captured in
Left up. It reads the phase 2 paper carefully and it is honest about the intervals.
Which phase 2 arm are you quoting, and at what week?
heart rate is the thing people report watching
Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.
Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.
What is the source for that figure — the published paper or a summary of it?
It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.
Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.
comparing reta phase 2 to sema phase 3 is comparing different things
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
Has anyone posted an independent test on this compound recently?
Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.
Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.
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