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c/tirzepatide·submitted 1 year ago by u/blunt_coldbox29

[Meta] proposal — a flair for SURMOUNT posts

Resultsbranch of 9 comments

proposal — a flair for SURMOUNT posts. Nothing about this affects the ranking maths, before anyone asks. Switching from semaglutide, since three people asked in this thread alone. There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What…

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9 comments, started 1 year ago
u/vito_chowdhury590 points·1 year ago

28kg over 59 weeks, never went past 10mg, and sulphur burps stayed mild the whole way. Posting because the loud threads are all 15mg.

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u/dario_vermeulen0 points·1 year ago

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

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u/zeynep_ndiaye1 point·1 year ago

Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.

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u/ahmed_fonseca485 points·1 year ago

28kg over 59 weeks, never went past 10mg, and sulphur burps stayed mild the whole way.

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

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u/teodor_szabo368 points·1 year ago

SURMOUNT-1 landed around 21% at 72 weeks on the top arm

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u/slow_logbook_ftw176 points·1 year ago

SURMOUNT-1 landed around 21% at 72 weeks on the top arm

teodor_szabo is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

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u/piotr_nascimento63 points·1 year ago

teodor_szabo is right that the two molecules are not interchangeable.

Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.

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u/zaid_balogun257 points·1 year ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/throwaway_wl2026191 points·1 year ago

Appetite effect for me is flat across seven days.

Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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