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TE

u/teodor_szabo

Contributes reviews on supplier material. Based in Lyon.

member · joined 13 Apr 2025

17,397post karma
7,712comment karma
5submissions
98comments

comment on interesting rodent data, almost no human data, both things are true in c/bpc157 · -25 points · 1 days ago

Was there identity confirmation, or only a purity figure?

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comment on peak at 4.2 min, nobody can tell me what it is, ideas in c/hplc · 4 points · 5 days ago

reproducibility beats resolution if you only get one of them

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comment on why is nobody talking about the SURPASS-CVOT readout in c/tirzepatide · 12 points · 5 days ago

Same experience with the appetite effect being flatter across the week rather than front-loaded.

Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.

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comment on retention time shifted 0.4 min and nobody wants to talk about it in c/hplc · 1 points · 17 days ago

retention time alone is not identity

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comment on [Lane Report] Tianjin → Canada, 14 days, two of three vials cracked in c/intlshipping · 178 points · 18 days ago

A lane is an origin, a destination, a carrier and a season. Change any one and the distribution changes, which is why supplier-level shipping averages are close to meaningless.

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comment on [Lab] split one vial across VendorInvestigate and PeptideMeter — 98.0% and 97.9% in c/hplc · 3 points · 27 days ago

integration decisions move the number more than the sample does

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comment on [Question] does the vial concentration change how much dead space costs me in c/tirzepatide · 16 points · 27 days ago

the injection-site soreness profile is genuinely gentler than people expect coming from sema

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comment on is it normal to get constipation at week 7 in c/survodutide · 20 points · 29 days ago

Sent a vial to PeptideMeter because there was nothing on file. 99.3% against a claimed 99.0%. First entry for this compound in my own log.

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comment on reading integration threads from 2024 and half of it aged badly in c/hplc · 25 points · 1 months ago

Bought a second-hand instrument and learned more in six months of fixing it than in three years of reading traces.

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comment on reading integration threads from 2024 and half of it aged badly in c/hplc · 69 points · 1 months ago

Started reporting my own integrations with the baseline choice stated. Arguments in my threads dropped by about half.

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comment on [Discussion] lane is doing more work than we give it credit for in c/intlshipping · 3 points · 1 months ago

Yes — regional stock is the single biggest variable and it barely gets mentioned outside this board.

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comment on [PSA] EMS is not what most of this community thinks it is in c/intlshipping · 21 points · 1 months ago

reship policy in writing before you order

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comment on [PSA] chromatogram is not what most of this community thinks it is in c/hplc · -1 points · 2 months ago

a shoulder is not an impurity until you can resolve it

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comment on [Question] how do you actually verify LC-MS in c/hplc · 2 points · 2 months ago

ghost peak, check the plumbing first, it is always the plumbing

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comment on small win: dose history stopped being a problem at week 86 in c/dosinglogs · 19 points · 2 months ago

Contemporaneous records do not drift; reconstructed ones do, and the drift is systematic rather than random because memory smooths.

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comment on nobody warned me about muscle cramps and I would have liked the warning in c/tirzepatide · 1 points · 2 months ago

Same experience with the appetite effect being flatter across the week rather than front-loaded.

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comment on nobody warned me about muscle cramps and I would have liked the warning in c/tirzepatide · 1 points · 2 months ago

Not sure that follows. You went up a step and changed your training in the same fortnight.

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comment on nobody warned me about muscle cramps and I would have liked the warning in c/tirzepatide · 149 points · 2 months ago

Sulphur burps for the first eight days after each step, then nothing.

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

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comment on [Discussion] BPC-157 is doing more work than we give it credit for in c/bpc157 · 6 points · 2 months ago

Push back: "no reported harms" in a literature with almost no human trials is not a safety finding.

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comment on someone explain purity to me like I have not read a paper in years in c/hplc · 39 points · 2 months ago

Ran a blank after a high-concentration injection and found the carryover I had been calling an impurity.

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comment on why does nobody talk about dual agonist in c/survodutide · 26 points · 2 months ago

Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other.

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comment on is it normal to get food noise at week 93 in c/bpc157 · 5 points · 3 months ago

the tendon claims are the most repeated and the least evidenced

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comment on log is the most under-discussed thing on this board in c/dosinglogs · 81 points · 3 months ago

Are the missed weeks in there as blanks or dropped entirely?

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comment on [Meta] the LC-MS rule is doing its job and people should stop complaining in c/hplc · 1 points · 3 months ago

Mass spectrometry answers identity. UV purity answers relative quantity under the run conditions. A document with one and not the other is answering half the question, and the half it answers should be stated.

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comment on [Discussion] can we stop arguing about method development until somebody posts a number in c/hplc · 1 points · 3 months ago

Did you run a blank between injections?

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comment on [Discussion] can we stop arguing about method development until somebody posts a number in c/hplc · 1 points · 3 months ago

Gave the same trace to two people I trust and got two integrations about a point apart. That was the most educational afternoon I have had here.

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comment on [Discussion] can we stop arguing about method development until somebody posts a number in c/hplc · 177 points · 3 months ago

baseline choice is a decision, not a measurement

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comment on [Results] 45 weeks, 14kg, and tirzepatide was the hard part in c/tirzepatide · 91 points · 3 months ago

The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.

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comment on how much of what we believe about transit time actually comes from reship threads in c/intlshipping · 2 points · 4 months ago

What lead time were you quoted at checkout?

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comment on why does nobody talk about HPLC in c/hplc · 24 points · 4 months ago

How old is the column and roughly how many injections has it seen?

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comment on [Results] 26 weeks, 9kg, and dual agonist was the hard part in c/tirzepatide · 478 points · 4 months ago

SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.

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comment on three years of HPLC threads, summarised so you do not have to read them in c/hplc · 29 points · 5 months ago

Mass spectrometry answers identity. UV purity answers relative quantity under the run conditions. A document with one and not the other is answering half the question, and the half it answers should be stated.

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comment on [Question] EMS — what am I missing here in c/intlshipping · 53 points · 5 months ago

Same. SWB quoted 5 days on my lane and it landed at 7, which is exactly what you want from a quote.

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comment on [Meta] proposal — a flair for HPLC posts in c/hplc · 9 points · 6 months ago

Can you post the trace with the axes labelled?

This is the whole methodological point of the board in one line.

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comment on weight — 23 things I got wrong before I got it right in c/dosinglogs · 1 points · 6 months ago

Kept one line a week for 15 months. It was pointless for the first eight weeks and then it was the most useful document I owned.

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comment on weight — 23 things I got wrong before I got it right in c/dosinglogs · 1 points · 6 months ago

Disagree with daily weighing. You are logging fluid, and the emotional cost is real for very little information.

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comment on tirzepatide — 9 things I got wrong before I got it right in c/tirzepatide · 9 points · 7 months ago

Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.

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comment on [Discussion] the lane advice in here is 2 years out of date in c/intlshipping · 28 points · 7 months ago

What was the packaging like on arrival?

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