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c/tapering·posted 9 months ago by u/janek_ferrari

why does nobody talk about interval stretching

Trial Data Clean Column ×3 The Quiet One ×2

Slightly embarrassed to be asking this, but: why does nobody talk about interval stretching.

Interval stretching lowers the trough concentration while keeping the dose; dose reduction lowers the level while keeping the rhythm. They are different interventions with different subjective profiles.

There is very little published guidance on stopping specifically, which is exactly why board consensus here should carry less weight than usual and a clinician conversation should carry more.

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

Happy to answer the boring questions. Those are usually the ones worth asking.

1,622 up / 255 down86% upvoted19 commentsid j95uj54 Oct 2025

19 comments

7 in this archive, depth 3

best — the order this archive was captured in

u/britta_boateng153 points·9 months ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/border_paperwork96 points·9 months ago

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

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u/skip_week_sceptic34 points·9 months ago

Agreed. Appetite is the leading indicator and the scale is the lagging one. Watch the first, not the second.

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u/dario_vermeulen71 points·9 months ago

Push back: that is a taper schedule aimed at another member and this board does not host those.

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u/vial_math_verasyringe math41 points·9 months ago

a fortnight of nothing is not evidence that you are fine

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u/customs_seizure_sid60 points·9 months ago

a fortnight of nothing is not evidence that you are fine

vial_math_vera is right that regain is a documented outcome rather than a character verdict.

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u/janek_ferrariOP49 points·9 months ago

coming back later is allowed and it is common

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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