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c/tapering·posted 1 year ago by u/customs_seizure_sid

reading regain threads from 2024 and half of it aged badly

Trial Data Cold Box ×1 Slow Clap ×2

reading regain threads from 2024 and half of it aged badly — a position I have arrived at slowly and would like tested.

Preparing to stop, as described by people here who have done it.

Write down where you are first: dose, date, weight, waist, and an honest note about how appetite feels. That page is what makes the following six months interpretable rather than a fog of impressions.

Decide in advance what you are watching for and over what period — appetite in the first month, weight over three, and a specific threshold at which you would want to revisit the decision. Have the conversation with a clinician before rather than after.

None of that is a schedule. It is a way of arriving at whatever happens next with information rather than with a vague sense of how it is going.

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.

1,343 up / 439 down75% upvoted61 commentsid gh3ilh30 Jan 2025

61 comments

21 in this archive, depth 5

best — the order this archive was captured in

u/preservative_free_p119 points·1 year ago

Why the first fortnight tells you nothing.

With a week-long half-life, exposure declines over several weeks after a final dose rather than ending with it. So the first two weeks after stopping are still a tail of the previous state, and the stability people report in that window is not evidence about the months after it.

The reports here are fairly consistent: appetite noticeably different somewhere in the second month, weight following later, and the trajectory strongly influenced by whether the habits from the losing phase survived. That is not a prediction for anybody in particular, and it is not a schedule — it is the shape of what members describe, which is the most this board can honestly offer.

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u/customs_seizure_sidOP82 points·1 year ago·edited

nobody here can write you a taper schedule

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u/marta_marchand63 points·1 year ago

Do you have a written baseline from before you started changing anything?

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u/marta_marchand17 points·1 year ago

have the conversation with a clinician before, not after

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u/naomi_ekstrom60 points·1 year ago

The habits are what carried it for a while. When they slipped, everything else followed, in that order.

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u/viktor_kirchner71 points·1 year ago

Stretching the interval or reducing the dose?

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[removed]26 points·1 year ago

[removed by moderator]

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u/janek_ferrari47 points·1 year ago

Stretching the interval or reducing the dose?

Disagreeing with this bit: stretching and reducing are different things and the post treats them as one.

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u/elin_varga18 points·1 year ago

Correction: that study measured regain after discontinuation, not loss of effect during treatment. Very different findings.

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u/hana_lehtinen37 points·1 year ago·edited

Disagree with the framing. Regain is the documented outcome after discontinuation; calling it a personal failure is both wrong and corrosive.

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u/teodor_lokken17 points·1 year ago

Agreed. Appetite is the leading indicator and the scale is the lagging one. Watch the first, not the second.

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u/janek_ferrari9 points·1 year ago

Yes — have the conversation before rather than after. That is the one piece of process advice this board can give.

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u/customs_seizure_sid4 points·1 year ago

stretching to ten days then twelve is the pattern people report

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u/arne_amankwah3 points·1 year ago

stretching to ten days then twelve is the pattern people report

Adding the one process step — write down where you are before you change anything.

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u/viktor_kirchner28 points·1 year ago

Agreed that returning later is common and it is treated here as ordinary rather than as a defeat.

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u/nikhil_lindqvist15 points·1 year ago·edited

Small fix — you have described interval stretching and called it a taper. The exposure profiles differ.

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u/coa_janitormod · c/coa11 points·1 year ago

a fortnight of nothing is not evidence that you are fine

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u/aleksi_lehtinen4 points·1 year ago

This. Decide in advance what you are watching for. Deciding in the middle of it is much harder.

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u/maintenance_mode_maxMOD22 points·1 year ago

Removed the taper schedule written for another member. Describe your own experience instead.

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u/careful_gradient20 points·1 year ago

What the evidence says about stopping, written plainly because the framing does real damage.

Withdrawal studies across this class consistently show substantial regain after discontinuation. Appetite typically returns first, well before weight changes. This is a finding about the pharmacology of a chronic condition, in the same way that blood pressure rises again when an antihypertensive is stopped.

People on this board quit in shame over an entirely predictable result, and then avoid coming back because they have interpreted it as a personal failure. It is not. Knowing that in advance is the single most useful thing this board can offer anybody planning to stop.

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u/valeria_cardoso-23 points·1 year ago

cost and supply are the two most common reasons and both are legitimate

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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