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c/tapering·posted 1 months ago by u/viktor_kirchner

the appetite return question that gets asked weekly, answered properly

Trial Data Well Actually ×8

the appetite return question that gets asked weekly, answered properly. It is the sort of thing everyone half-believes and nobody writes down.

Stopped for cost reasons. Appetite came back at about week 13, well before the scale moved, exactly as this board said it would.

Wrote down where I was before changing anything. That single page made the following six months interpretable.

Regained most of it over a year and spent that year assuming it was my fault. It was not; it is what the literature describes.

Corrections welcome, especially the pedantic ones. Pedantry is how this board earns its reputation.

985 up / 201 down83% upvoted48 commentsid 1em38w10 Jun 2026

48 comments

25 in this archive, depth 5

best — the order this archive was captured in

u/vikram_asante194 points·1 months ago

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

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u/maintenance_mode_maxMOD97 points·1 months ago

Left up. It is honest about the reason for stopping and about the timeline.

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[deleted]41 points·1 months ago

[deleted]

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u/nikhil_lindqvist-7 points·1 months ago

Stretched from seven days to ten to twelve over four months. Appetite told me where the limit was each time.

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u/viktor_kirchner128 points·1 months ago

Agreed. Appetite is the leading indicator and the scale is the lagging one. Watch the first, not the second.

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u/rekha_teixeira40 points·1 months ago

the habits are what has to carry it afterwards

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u/preservative_free_p19 points·1 months ago

Right, and the habits from the losing phase are the part that has to outlive the dose.

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u/zeynep_weiss89 points·1 months ago

Have you had the conversation with a clinician yet?

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u/quiet_reader_9950 points·1 months ago

Correction: that study measured regain after discontinuation, not loss of effect during treatment. Very different findings.

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u/andres_restrepo45 points·1 months ago

Push back: that is a taper schedule aimed at another member and this board does not host those.

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u/jarno_adebayo85 points·1 months ago

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

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u/zeynep_weiss28 points·1 months ago

decide what you are watching for before you stop

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u/priya_weiss53 points·1 months ago

What is prompting the decision — cost, supply, side effects, or something else?

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u/lift_heavy_thingsresistance training37 points·1 months ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/viktor_kirchnerOP26 points·1 months ago

have the conversation with a clinician before, not after

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u/vikram_ferreira38 points·1 months ago

stopping is a plan, not an event

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u/ines_boateng18 points·1 months ago

Had the conversation with a clinician before stopping rather than after. Considerably easier that way round.

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u/ignacio_silva17 points·1 months ago

This. Decide in advance what you are watching for. Deciding in the middle of it is much harder.

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u/ines_boateng39 points·1 months ago

Disagree with the framing. Regain is the documented outcome after discontinuation; calling it a personal failure is both wrong and corrosive.

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u/viktor_kirchnerOP15 points·1 months ago

Stopped abruptly once and gradually once. The gradual one was easier to interpret because I could see what was changing.

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u/ilias_nakamura11 points·1 months ago

The habits are what carried it for a while. When they slipped, everything else followed, in that order.

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u/marta_weiss13 points·1 months ago

Went back on after eight months away. Nobody here made me feel bad about it, which mattered more than I expected.

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u/viktor_kirchnerOP6 points·1 months ago·edited

Is this a pause or a stop? They are different plans.

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u/vikram_ferreira17 points·1 months ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/britta_boateng5 points·1 months ago

Yes — the withdrawal literature is consistent and it is a pharmacological finding, not a moral one.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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