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c/tapering·submitted 28 days ago by u/vikram_ferreira

[Results] 56 weeks on 2.4mg, full numbers, ask me anything boring

Resultsbranch of 7 comments

Check-in as promised in the title: 56 weeks on 2.4mg, full numbers, ask me anything boring. The relevant figures are 56 weeks and 2.4mg, and they come from the same log I have kept the whole time. Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically…

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7 comments, started 26 days ago
u/helga_vermeulen64 points·26 days ago

Is this a pause or a stop? They are different plans.

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u/ahmed_cardoso31 points·26 days ago

Yes — have the conversation before rather than after. That is the one piece of process advice this board can give.

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u/injection_site_iris15 points·26 days ago·edited

That reads as advice to stop, which is not something anyone here should be offering.

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u/fabio_lehtinen9 points·25 days ago

That reads as advice to stop, which is not something anyone here should be offering.

Disagreeing with this bit: stretching and reducing are different things and the post treats them as one.

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u/dizzy_on_standing4 points·25 days ago

What is prompting the decision — cost, supply, side effects, or something else?

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u/piotr_bruun3 points·25 days ago

How long were you at the dose you are coming off?

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u/ines_boateng-21 points·25 days ago

Had the conversation with a clinician before stopping rather than after. Considerably easier that way round.

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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