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c/sideeffects·posted 9 months ago by u/gentle_correction

tried fatigue for 19 weeks. here is what happened.

Management Well Actually ×7 Cold Box ×3 Slow Clap ×3

tried fatigue for 19 weeks. here is what happened. Making the case below, and I expect to lose some of it in the comments.

Pulling the figures out of the title: 19 weeks. All of it is written down as it happened rather than reconstructed.

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

Happy to answer the boring questions. Those are usually the ones worth asking.

4,418 up / 520 down89% upvoted25 commentsid euuszv9 Oct 2025

25 comments

9 in this archive, depth 3

best — the order this archive was captured in

u/rohan_steiner730 points·9 months ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 32 probably does not, and that is worth saying to a clinician rather than to us.

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u/mikkel_kimani329 points·9 months ago

Yes. Holding the dose is a real option and it does not mean you have failed at anything.

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u/naomi_erdogan102 points·9 months ago

Has anything else changed in the same window?

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u/fibre_forward-24 points·9 months ago

Keeping a log, and what to put in it.

One line a day: dose, day since injection, what the symptom was and how bad out of five, and roughly what you ate. Two months of that fits on one page and the pattern is obvious on paper in a way it never is in your head.

Mine showed a clean day-two-to-day-four window I had been describing as "random". Once you can see the pattern you can plan around it, and planning around it is most of the relief.

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u/sena_teixeira1 point·9 months ago

Keeping a log, and what to put in it.

Adding to this — holding the dose rather than stepping is the option people forget they have.

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u/quiet_moderatormod1 point·9 months ago

Yes — the day-two-to-day-four window is so consistent across this board that it is almost diagnostic.

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u/priya_weiss1 point·9 months ago

the food noise going quiet is the effect people came for, and early fullness is the toll for the first fortnight

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u/idris_iyer1 point·9 months ago

if it is severe or persistent that is a clinician question, not a board question

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u/rania_marchand1 point·9 months ago

holding a dose an extra month is a legitimate answer to bad tolerance

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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