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c/sideeffects·posted 7 months ago by u/rania_diallo

small win: nausea stopped being a problem at week 58

Question Well Actually ×7 Sourced ×3 Clean Column ×2

Update, and the title has the headline: small win: nausea stopped being a problem at week 58.

injection-site soreness for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.

4,550 up / 329 down93% upvoted40 commentsid 19xvr626 Dec 2025

40 comments

19 in this archive, depth 4

best — the order this archive was captured in

u/long_post_larry-18 points·7 months ago

The pattern almost everyone here describes, written out once so it can be linked.

A step up is followed by a rough window — commonly reflux arriving the day after the shot and easing by day four, worst in the first fortnight, then flattening out. At a stable dose it usually settles further. Constipation and fatigue tend to track intake and fluid rather than the compound directly, which is why the unglamorous answers work.

What sits outside that pattern: severe pain, symptoms that appear from nowhere weeks into a stable dose, or anything getting worse rather than better over a month. None of that is a board question and none of us can answer it for you.

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u/blunt_coldbox_20241 point·7 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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[removed]1 point·7 months ago

[removed by moderator]

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u/brigade_detector673 points·7 months ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/elin_trevino466 points·7 months ago

Which day of the week relative to the shot does it hit?

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u/adaeze_batista208 points·7 months ago

sulphur burps are unpleasant and they are not dangerous

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u/adaeze_batista340 points·7 months ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/rania_dialloOP0 points·7 months ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/saskia_lokken1 point·7 months ago

Yes — the day-two-to-day-four window is so consistent across this board that it is almost diagnostic.

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u/gentle_correctionMOD160 points·7 months ago

Left up. It is a description of one person’s week and it is flagged as such.

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u/iman_castellanos286 points·7 months ago

Same pattern here. It settled at a stable dose without me doing anything clever.

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u/isabela_nilsen145 points·7 months ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/aa_analysis_andy0 points·7 months ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/mikkel_kimani100 points·7 months ago

How long after a step up did this start?

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u/sanne_laurent47 points·7 months ago·edited

How long after a step up did this start?

mikkel_kimani is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/constipation_clubside effects35 points·7 months ago

What is intake actually looking like — fibre and water especially?

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u/coring_the_stopper60 points·7 months ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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