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c/sideeffects·posted 2 months ago by u/kavya_kravchenko

my ApoB moved and I cannot work out whether constipation is why

PSA Receipts ×6 Slow Clap ×1

my ApoB moved and I cannot work out whether constipation is why. Change my mind, genuinely — I have no stake in being right about this.

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

Tell me where this is wrong. That is the useful part of posting it.

14,593 up / 12,764 down53% upvoted31 commentsid 19dbf77 May 2026

31 comments

22 in this archive, depth 5

best — the order this archive was captured in

u/sanne_laurent252 points·2 months ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/liv_vukovic206 points·2 months ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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u/nausea_notesside effects0 points·2 months ago

Agreed. Slowing down at meals did more for my reflux than everything I bought to fix it, which was embarrassing to discover.

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u/hassan_castellanos55 points·2 months ago

Yes — the day-two-to-day-four window is so consistent across this board that it is almost diagnostic.

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u/neha_rahimi120 points·2 months ago

sulphur burps are unpleasant and they are not dangerous

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u/sanne_laurent82 points·2 months ago

sulphur burps for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

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u/neha_rahimi21 points·2 months ago·edited

nobody warns you about how much of this is timing rather than dose

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u/rania_diallo78 points·2 months ago

fatigue plus low intake is usually just low intake

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u/ipamorelin_i38 points·2 months ago

smaller meals, earlier, is the boring advice that works

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u/iman_falk33 points·2 months ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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u/peptidemeter_pat59 points·2 months ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/plain_titration_2024-9 points·2 months ago

On buying things to fix side effects, which I did extensively and would not do again.

The interventions that changed anything for me were all behavioural and free: smaller meals, eating slower, stopping food a few hours before sleep, more fibre and considerably more water. The things I bought did nothing I could detect, and I was motivated to detect something.

The other lever, which people forget, is time at dose. Holding rather than stepping is a legitimate plan and it fixed my tolerance where nothing else did.

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u/ahmed_rasmussen37 points·2 months ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/rohan_steiner29 points·2 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/rafael_ostergaard42 points·2 months ago

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

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u/rania_diallo10 points·2 months ago

Bought four different things to fix my nausea. What actually worked was eating half as fast.

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u/ahmed_rasmussen5 points·2 months ago

fibre and water before you buy anything to fix it

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u/kavya_kravchenkoOP21 points·2 months ago

Which day of the week relative to the shot does it hit?

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u/clara_weiss15 points·2 months ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/kavya_kravchenkoOP6 points·2 months ago

Nobody warned me about constipation and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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