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c/semaglutide·posted 8 months ago by u/camila_sandvik

small win: weekly dosing stopped being a problem at week 23

Results Cold Box ×8 Slow Clap ×1 Clean Column ×1

small win: weekly dosing stopped being a problem at week 23, and the part I actually want to talk about is at the bottom.

Sat at 0.5mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the sulphur burps.

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

I will update this if the picture changes rather than quietly leaving it up.

4,138 up / 614 down87% upvoted42 commentsid g6tw2p15 Nov 2025

42 comments

16 in this archive, depth 4

best — the order this archive was captured in

u/kaplan_meier_kim267 points·8 months ago

The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.

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u/niels_lindqvist147 points·8 months ago

That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.

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u/joaquin_stanescu-31 points·8 months ago

STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure

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u/oskar_ibarra123 points·8 months ago

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

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u/titration_marshalMOD66 points·8 months ago·edited

Standard reminder: no personal titration plans for other members, and no medical advice. Everything else is fine.

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u/kenji_vasquez54 points·8 months ago

Agreed, and the bit people skip is that the ladder is a tolerance ladder. It is not a potency ranking.

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u/rafael_ostergaard96 points·8 months ago·edited

Not convinced. You changed the dose and the week at the same time, so you cannot attribute the change to either.

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u/ahmed_okafor65 points·8 months ago

Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.

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u/nikhil_teixeira57 points·8 months ago

Week 66: 15kg down, injection-site soreness basically gone since about week 3, and the honest headline is that nothing dramatic happened. It was boring and it worked.

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u/two_mil_or_one30 points·8 months ago

Genuine question — is the appetite effect still there, or is it just the scale that has paused?

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u/rasmus_kimani8 points·8 months ago

Cosigning. The appetite change and the scale change ran about three weeks apart for me too.

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u/iman_castellanos31 points·8 months ago

Yes. Week 37 is when almost everybody writes the "is it still working" post, and almost everybody is fine.

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u/camila_sandvikOP17 points·8 months ago

Minor fix — the half-life is about a week, not about a day. The rest of your point stands.

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u/lane_map_larrylogistics4 points·8 months ago

if 2.4mg is working there is no prize for going up

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u/nadia_bakker3 points·8 months ago

Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.

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u/osman_ferrari20 points·8 months ago

Kept a log from week one and the single most useful column turned out to be waist, not weight.

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