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c/semaglutide·posted 2 years ago by u/source_or_silence

[Question] how do you actually verify Wegovy

Question Clean Column ×7 Receipts ×3

how do you actually verify Wegovy. I am not trying to be the "source?" guy. I would just like a source.

My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.

The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

1,914 up / 699 down73% upvoted58 commentsid 8q5mfu20 Sep 2023

58 comments

23 in this archive, depth 5

best — the order this archive was captured in

u/oskar_ibarra166 points·2 years ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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u/source_or_silenceOP68 points·2 years ago

dose day drift of a day either way is fine, the curve barely notices

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u/quiet_moderatorMOD87 points·2 years ago

Leaving this up. It is a check-in, it has numbers, and it is honest about being one person.

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u/rafael_ostergaard87 points·2 years ago·edited

The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.

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u/source_or_silence30 points·2 years ago

Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.

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u/rania_diallo12 points·2 years ago

Minor fix — the half-life is about a week, not about a day. The rest of your point stands.

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u/source_or_silenceOP-19 points·2 years ago

Minor fix — the half-life is about a week, not about a day.

Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.

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u/ismael_chukwu9 points·2 years ago

Are you measuring anything other than weight? Waist is usually the one that keeps moving.

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u/ravi_sandvik12 points·2 years ago

Cosigning. The appetite change and the scale change ran about three weeks apart for me too.

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[removed]8 points·2 years ago

[removed by moderator]

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u/kaplan_meier_kim52 points·2 years ago

Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.

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u/ewan_tulloch24 points·2 years ago

Yes. Week 59 is when almost everybody writes the "is it still working" post, and almost everybody is fine.

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u/marit_coelho8 points·2 years ago

protein first, then everything else gets easier

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u/kenji_vasquez43 points·2 years ago

This matches me almost exactly, right down to the food noise showing up on the second day and being gone by the fourth.

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u/greta_lokken20 points·2 years ago·edited

This matches me almost exactly, right down to the food noise showing up on the second day and being gone by the fourth.

Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.

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u/slow_logbook_notes31 points·2 years ago

nausea that arrives on day two and fades by day four is the standard shape

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u/source_or_silenceOP24 points·2 years ago

the appetite signal and the scale move on different clocks

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u/lane_map_larrylogistics19 points·2 years ago

Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.

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u/anya_salgado7 points·2 years ago

2.4 is a ceiling, not a target

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u/rasmus_kimani0 points·2 years ago

Agreed, and the bit people skip is that the ladder is a tolerance ladder. It is not a potency ranking.

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u/rina_bergstrom1 point·2 years ago·edited

Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.

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u/meta_analysis_mo1 point·2 years ago

stalling at 2.4mg is information, not a verdict

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