[Titration] stayed at 0.5 for eleven weeks and it was the right call
Thinking out loud about this: stayed at 0.5 for eleven weeks and it was the right call.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Week 18: 8kg down, sulphur burps basically gone since about week 7, and the honest headline is that nothing dramatic happened. It was boring and it worked.
Tell me where this is wrong. That is the useful part of posting it.
best — the order this archive was captured in
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
staying at 0.5mg for an extra month is a legitimate plan
That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.
Did protein intake change in the same window?
Did protein intake change in the same window?
Disagree with this specific line. A pause at 1.7mg is not evidence that 1.7mg has stopped working.
the scale is the least sensitive instrument you own
the first four weeks are a tolerance check, not a weight-loss phase
First month I lost almost nothing and nearly quit. Month two and three were where it all happened.
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
food noise made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.
Sat at 2.4mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the muscle cramps.
Retitled to match the body. The original promised a comparison the post does not make.
Does early fullness track the day after the shot, or is it there all week?
stalling at 0.25mg is information, not a verdict
Are you measuring anything other than weight? Waist is usually the one that keeps moving.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the early fullness usually fades at a stable dose.
My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.
Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.
The mental model that finally made this click for me: there are two curves, and people watch the wrong one.
The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.
Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.