tried Ozempic for 21 weeks. here is what happened.
tried Ozempic for 21 weeks. here is what happened — a position I have arrived at slowly and would like tested.
To save the first four comments: 21 weeks.
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.
best — the order this archive was captured in
On the "everybody ends up at 2.4" claim, which comes up every few weeks.
The escalation schedule in the trials was designed to get people to a fixed study dose. Real use is not a trial. The dose that keeps your appetite quiet with side effects you can live with is the dose, and for a lot of people on this board that has been 0.5mg for a very long time.
The counter-argument, which is fair: some people genuinely do need the top of the range, and staying low out of caution costs them months. That is a conversation with someone who knows your history, not with us.
That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.
Leaving this up. It is a check-in, it has numbers, and it is honest about being one person.
the food noise going quiet is the effect people actually describe
Are you measuring anything other than weight? Waist is usually the one that keeps moving.
What did week 20 look like compared with this one? The month either side is the useful comparison.
Genuine question — is the appetite effect still there, or is it just the scale that has paused?
I would push back gently. Going up because the scale paused is the single most common mistake described on this board.
Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.
the scale is the least sensitive instrument you own
This matches me almost exactly, right down to the constipation showing up on the second day and being gone by the fourth.
Strongly agree on protein. It did more for my constipation than any of the things I bought to fix my constipation.
Agreed, and the bit people skip is that the ladder is a tolerance ladder. It is not a potency ranking.
2.4 is a ceiling, not a target
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
the appetite signal and the scale move on different clocks
the appetite signal and the scale move on different clocks
rania_diallo is describing the standard shape here and it matches the trial data better than most anecdotes do.
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
Not convinced. You changed the dose and the week at the same time, so you cannot attribute the change to either.
Not convinced.
Disagree with this specific line. A pause at 1.0mg is not evidence that 1.0mg has stopped working.
Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.
do not chase somebody else’s titration schedule, they are not you
Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.
- 1the food noise going quiet is the effect people actually describe8 comments in this branch · started by u/lane_map_larry