genuine question about titration that I am slightly embarrassed to ask
Trying to get a straight answer on this: genuine question about titration that I am slightly embarrassed to ask.
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the early fullness usually fades at a stable dose.
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
I will update this if the picture changes rather than quietly leaving it up.
best — the order this archive was captured in
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
What did week 67 look like compared with this one? The month either side is the useful comparison.
[deleted]
STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
the appetite signal and the scale move on different clocks
Standard reminder: no personal titration plans for other members, and no medical advice. Everything else is fine.
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
This matches me almost exactly, right down to the constipation showing up on the second day and being gone by the fourth.
protein first, then everything else gets easier
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
the scale is the least sensitive instrument you own
Did protein intake change in the same window?
Does fatigue track the day after the shot, or is it there all week?
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
if 0.5mg is working there is no prize for going up
The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes.
This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.
Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.
Are you measuring anything other than weight? Waist is usually the one that keeps moving.
the food noise going quiet is the effect people actually describe
nausea that arrives on day two and fades by day four is the standard shape
Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.
nausea that arrives on day two and fades by day four is the standard shape
anya_erdogan is describing the standard shape here and it matches the trial data better than most anecdotes do.
dose day drift of a day either way is fine, the curve barely notices
staying at 0.5mg for an extra month is a legitimate plan
week 19 plateau is the most predictable thing in this entire board
- 1The weekly interval comes out of the half-life — roughly a week — so you are…10 comments in this branch · started by u/micro_bump_mick
- 2the appetite signal and the scale move on different clocks7 comments in this branch · started by u/vikram_ferreira