21 months in and semaglutide is still the thing I get wrong
21 months in and semaglutide is still the thing I get wrong. Numbers below. Ask me the boring questions, they are the useful ones. To save the first four comments: 21 months. My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all. Sat at 1.0mg for four months because it was doing…
The mental model that finally made this click for me: there are two curves, and people watch the wrong one.
The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.
Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.
dose day drift of a day either way is fine, the curve barely notices
sema is weekly for a reason, the half-life does the smoothing
nausea that arrives on day two and fades by day four is the standard shape
Did protein intake change in the same window?
do not chase somebody else’s titration schedule, they are not you